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A photo of Assistant Professor Wesley Campbell, UCLA Physics & Astronomy

UCLA physicists develop world’s best quantum bits

A photo of Assistant Professor Wesley Campbell, UCLA Physics & Astronomy

Assistant Professor Wesley Campbell, UCLA Physics & Astronomy (Photo Credit: UCLA)

A team of researchers at UCLA has set a new record for preparing and measuring the quantum bits, or qubits, inside of a quantum computer without error. The techniques they have developed make it easier to build quantum computers that outperform classical computers for important tasks, including the design of new materials and pharmaceuticals. The research is published in the peer-reviewed, online open-access journal, npj Quantum Information, published by Nature and including the exceptional research on quantum information and quantum computing.

Currently, the most powerful quantum computers are “noisy intermediate-scale quantum” (NISQ) devices and are very sensitive to errors. Error in preparation and measurement of qubits is particularly onerous: for 100 qubits, a 1% measurement error means a NISQ device will produce an incorrect answer about 63% of the time, said senior author Eric Hudson, a UCLA professor of physics and astronomy.

To address this major challenge, Hudson and UCLA colleagues recently developed a new qubit hosted in a laser-cooled, radioactive barium ion. This “goldilocks ion” has nearly ideal properties for realizing ultra-low error rate quantum devices, allowing the UCLA group to achieve a preparation and measurement error rate of about 0.03%, lower than any other quantum technology to date, said co-senior author Wesley Campbell, also a UCLA professor of physics and astronomy.

The development of this exciting new qubit at UCLA should impact almost every area of quantum information science, Hudson said. This radioactive ion has been identified as a promising system in quantum networking, sensing, timing, simulation and computation, and the researchers’ paper paves the way for large-scale NISQ devices.

Co-authors are lead author Justin Christensen, a postdoctoral scholar in Hudson’s laboratory, and David Hucul, a former postdoctoral scholar in Hudson and Campbell’s laboratories, who is now a physicist at the U.S. Air Force Research Laboratory.

The research is funded by the U.S. Army Research Office.

Campbell and Hudson are primary investigators of a major $2.7 million U.S. Department of Energy Quantum Information Science Research project to lay the foundation for the next generation of computing and information processing, as well as many other innovative technologies.

This article originally appeared on the UCLA Physical Sciences website.

A photo of Sasha Gill-Ljunghammer and Hieu Nguyen.

UCLA’s 2020-2021 Beckman Scholars Announced

A photo of Sasha Gill-Ljunghammer and Hieu Nguyen.

From left: Sasha Gill-Ljunghammer and Hieu Nguyen (Photo Courtesy of UCLA Department of Chemistry & Biochemistry)

Undergraduate researchers Sasha Gill-Ljunghammer (Tolbert Group) and Hieu Nguyen (Torres group) have been selected as 2020-2021 Beckman Scholars.

The 2020-2021 Beckman Research Scholarship at UCLA is directed through the Office of the Vice Provost for Undergraduate Education and administered by the Undergraduate Research Center (URC)-Sciences. The scholarship is awarded to outstanding undergraduate researchers who are majoring in Chemistry, Biochemistry, Microbiology, Immunology, and Molecular Genetics; or Molecular, Cell, and Developmental Biology, and who are committed to completing an honors thesis or a comprehensive 199 project under the supervision of a UCLA Beckman Faculty.

The $21,000 award will be distributed over one academic year and two summers, plus $2,800 for travel and research supplies.

Sasha Gill-Ljunghammer is a third-year chemistry major conducting research in Professor Sarah Tolbert’s laboratory where her research focuses on tuning superparamagnetic nanocrystals for use in multiferroic composite materials where magnetism can be fully switched on and off using an applied electric bias. Sasha is a transfer student from Schoolcraft Community College. While at Schoolcraft, she gained experience researching metal-organic frameworks at the University of Michigan-Ann Arbor. “I immediately fell in love with the challenging, yet rewarding, work that research demands,” Sasha said. “I have always had a deep appreciation for the sciences and I strive to share this passion by pursuing a career in academia. I hope to expand the boundaries of human knowledge and lead research that will contribute to the global environment.”

“Beckman Scholars is an outstanding program for undergraduate researchers, and Sasha is the kind of capable, passionate student who will make the most of this opportunity,” said her research advisor Professor Sarah Tolbert.

Hieu Nguyen is a third-year Molecular, Cell and Developmental Biology (MCDB) major conducting research in Professor Jorge Torres’ laboratory where his research focuses on identifying novel drugs that will guide senescent cells away from their current state. “The discovery of these compounds will increase the efficacy of DNA-damaging drugs by preventing the formation of tumor-promoting environments induced by cell senescence,” Hieu explained. Outside of his laboratory work, Hieu also competes for UCLA’s archery team, works as a CPR instructor, and volunteers both for UCLA’s Mattel Childrens’ Hospital and at a student shelter. He intends to pursue a career in pediatric oncology which is rooted both in research and clinical practice.

“I am extremely proud of Hieu,”said his research advisor Professor Jorge Torres. “Hieu represents the best that UCLA undergraduate researchers have to offer. He has a contagious curiosity and a keen interest in understanding complex biological systems at the molecular level. Hieu’s outstanding intellectual, critical thinking and research abilities have prepared him to carry out his independent studies successfully and I look forward to seeing the great things that he can accomplish.”

This article originally appeared on UCLA Department of Chemistry & Biochemistry’s website

 

A photo of Dr. Steven Jonas, Jason Belling and Paul Weiss of UCLA .

A step toward a more efficient way to make gene therapies to attack cancer, genetic disorders

A photo of Dr. Steven Jonas, Jason Belling and Paul Weiss of UCLA .

(From left) Dr. Steven Jonas, Jason Belling and Paul Weiss of UCLA (Photo Credit: Reed Hutchinson)

A UCLA-led research team today reports that it has developed a new method for delivering DNA into stem cells and immune cells safely, rapidly and economically. The method, described in the journal Proceedings of the National Academy of Sciences, could give scientists a new tool for manufacturing gene therapies for people with cancer, genetic disorders and blood diseases.

The study’s co-senior author is Paul Weiss, a UCLA distinguished professor of chemistry and biochemistry, of bioengineering and of materials science and engineering. “We are figuring out how to get gene-editing tools into cells efficiently, safely and economically,” he said. “We want to get them into enormous numbers of cells without using viruses, electroshock treatments or chemicals that will rip open the membrane and kill many of the cells, and our results so far are promising.”

In current practice, cells used for genetic therapies are sent to specialized labs, which can take up to two months to produce an individualized treatment. And those treatments are expensive: A single regimen for one patient can cost hundreds of thousands of dollars.

“We hope our method could be used in the future to prepare treatments that can be performed at the patient’s bedside,” Weiss said.

The method could be used with CRISPR, the genetic engineering technique that enables DNA to be edited with remarkable precision. However, using CRISPR efficiently, safely and economically in medical therapies has proven to be a challenge — one this new method may be able to solve.

The technique uses high-frequency acoustic waves coupled with millions of cells that flow through an “acoustofluidic device” in a cell culture liquid. The device was invented by the research team as part of the study; inside of it are tiny speakers that convert electrical signals to mechanical vibrations that are used to manipulate the cells.

That procedure opens up pores along the cells’ membranes that allow DNA and other biological cargo to enter the cells, and it enables the researchers to insert the cargo without the risk of damaging the cells by contacting them directly.

Dr. Steven Jonas, the study’s co-senior author and a UCLA clinical instructor in pediatrics, likened the soundwaves’ ability to move cells to the experience when audience members actually feel the sound at a concert.

“At a concert hall, you can feel the bass — and if you can feel the sound, the cell can feel the acoustic wave,” said Jonas, a member of the California NanoSystems Institute at UCLA, the UCLA Jonsson Comprehensive Cancer Center and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. “We can engineer the acoustic waves to direct the cells as needed.”

The researchers delivered short strands of DNA called plasmids into human blood cells and blood-forming stem cells that were intended specifically for laboratory research, and pumped millions of such cells through the acoustofluidic device. Once inside a cell, a plasmid can be made into a protein that may be missing or damaged, or it can give the cell new capabilities.

“When combined with new gene-editing approaches, the method enables us to correct a DNA sequence that is miscoded in a disease,” said Weiss, who also is a member of CNSI.

Plasmids used as templates for gene editing can make the correction because they have the right coded sequence for the desired protein, he explained.

Lead author Jason Belling, a UCLA graduate student in chemistry and biochemistry, was able to insert plasmids into the model cells used for testing about 60% of the time, without using any chemical and physical treatments.

“The viability is very high compared with other techniques,” Weiss said, “but we still want higher efficiencies and are working toward that.”

Jonas — whose expertise is in treating childhood cancer and blood disorders — said the research has the potential to benefit adults and children with cancer, immune system disorders and genetic diseases.

“If the delivery works, and it seems to, this research is an important step toward bringing new therapies more broadly to the patients who need them,” Jonas said. “Traditionally, we have treated cancers with chemotherapy, surgery, radiation and bone marrow transplantations. Now, we’re at an amazing era of medicine, where we can use different types of gene therapies that can train the immune system to fight cancer.”

A photo of a prototype of the acoustofluidic device developed by UCLA researchers.

A prototype of the acoustofluidic device developed by UCLA researchers. (Photo Credit: Reed Hutchinson)

Jonas said some existing treatments can take a patient’s T cells and adapt them with a gene that encodes for a receptor that allows it to target the cancer.

“We want to be the delivery service that gets these therapeutic packages to the cells,” he said. “I want to treat my patients with cells that are engineered in this way.”

For the technique to lead to viable treatments for disease, it would need to allow doctors  to process at least a couple hundred million cells — and in some cases, billions of cells — safely, rapidly and cost-effectively for each patient.

The new approach is still the subject of research and is not available to treat human patients.

The study’s other co-authors include Duke University professor Tony Huang, a pioneer of acoustofluidics and a UCLA alumnus; Dr. Stephen Young, distinguished professor of medicine and human genetics at the David Geffen School of Medicine at UCLA; and Dr. Satiro De Oliveira, a UCLA assistant professor of pediatrics.

The study was funded in part through a National Institutes of Health Director’s Early Independence Award for Jonas; the University of California Center for Accelerated Innovation; and Belling’s predoctoral fellowship through the National Heart, Lung, and Blood Institute. Jonas also has received young investigator awards from the Alex’s Lemonade Stand Foundation for Childhood Cancer Research, Hyundai Hope on Wheels Foundation for Pediatric Cancer Research, and the Tower Cancer Research Foundation. UCLA’s Technology Development Group Innovation Fund also provided funding.

Weiss’ research group has applied for patents on the acoustofluidic device and related devices, working with the Technology Development Group.

This article originally appeared in the UCLA Newsroom.

Keeping Our First Responders in LA County Hospitals Safe

A photo of a first responder receives safety glasses and goggles.

A first responder receives safety glasses and goggles. (Photo Courtesy of UCLA Department of Chemistry and Biochemistry)

The Department of Chemistry and Biochemistry, spurred on by Professor Neil Garg, donated hundreds of safety glasses and goggles to help keep first responders in Los Angeles County hospitals safe. The distribution, orchestrated in a single weekend, was a way to express thanks to the selfless medical personnel in Los Angeles.

This post originally appeared on the Department of Chemistry and Biochemistry’s Facebook.

A photo of Lynn Vavreck and Miguel García-Garibay.

Two elected to American Academy of Arts and Sciences

A photo of Lynn Vavreck and Miguel García-Garibay.

From left: Lynn Vavreck, Miguel García-Garibay

Six exceptional UCLA professors and leaders — including the UCLA College’s Physical Sciences Dean Miguel García-Garibay and Political Science Professor Lynn Vavreck — were elected April 23 to the American Academy of Arts and Sciences, one of the nation’s most prestigious honorary societies. The other honorees include School of Law Dean Jennifer Mnookin, Education Professor Pedro Noguera, environmental champion Mary Nichols and Hammer Museum Director Ann Philbin.

“I am delighted to congratulate each of this year’s UCLA inductees, who are all deserving of this wonderful honor,” UCLA Chancellor Gene Block said. “Election to the American Academy of Arts and Sciences is a testament to the exceptional work of our scholars and leaders. The entire campus community can take pride in this news and their many accomplishments.”

A total of 276 artists, scholars, scientists and leaders in the public, nonprofit and private sectors who were elected to the Academy today. More about UCLA’s honorees:

Miguel García-Garibay, dean of the UCLA Division of Physical Sciences and professor of chemistry and biochemistry, has earned worldwide recognition in the fields of artificial molecular machines, organic photochemistry, solid-state organic chemistry and physical organic chemistry. He studies the interaction of light and molecules in crystals. Light can have enough energy to break and make bonds in molecules, and García-Garibay’s research team has shown that crystals offer an opportunity to control the outcome of these chemical reactions.

His research has applications for green chemistry — the design of chemical products and processes that reduce or eliminate the generation of hazardous substances — and it could lead to the production of specialty chemicals that would be very difficult to produce using traditional methods. Among his many honors, he was elected a fellow of the American Chemical Society in 2019.

Lynn Vavreck is UCLA’s Marvin Hoffenberg Professor of American Politics and Public Policy, a contributing columnist to the Upshot at the New York Times, and a recipient of many awards and honors, including the Andrew F. Carnegie Prize in the Humanities and Social Sciences. She is the author of five books, including “Identity Crisis: The 2016 Presidential Campaign and the Battle for the Meaning of America” and “The Gamble: Choice and Chance in the 2012 Presidential Election,” which has been described as the “definitive account” of that election.

Consultants in both political parties refer to her work on political messaging in “The Message Matters” as required reading for presidential candidates. “Identity Crisis” was awarded the 2019 Richard E. Neustadt Prize for the Best Book on Executive Politics by the Presidents and Executive Politics Section of the American Political Science Association.

Vavreck’s 2020 election project, Nationscape, is the largest study of presidential elections ever conducted in the United States. Interviewing more than 6,000 people a week, Nationscape will complete 500,000 interviews before next January’s inauguration.

► Read more about the Nationscape election project.

“The members of the class of 2020 have excelled in laboratories and lecture halls, they have amazed on concert stages and in surgical suites, and they have led in board rooms and courtrooms,” said David Oxtoby, president of the Academy. “With [the] election announcement, these new members are united by a place in history and by an opportunity to shape the future through the Academy’s work to advance the public good.”

The American Academy of Arts and Sciences was founded in 1780 by John Adams, John Hancock and others who believed the new republic should honor exceptionally accomplished individuals. Previous fellows have included George Washington, Benjamin Franklin, Alexander Hamilton, Ralph Waldo Emerson, Albert Einstein, Charles Darwin, Winston Churchill, Martin Luther King Jr. and Nelson Mandela.

It also is an independent policy research center that undertakes studies of complex and emerging problems. Current academy members represent today’s innovative thinkers in many fields and professions, including more than 250 Nobel and Pulitzer Prize winners.

This article originally appeared in the UCLA Newsroom.

An image of dust over the Sahara Desert.

Earth’s atmosphere far dustier than previously believed

An image of dust over the Sahara Desert.

Dust over the Sahara Desert (Photo Credit: NASA GSFC)

Dust is a key component of Earth’s climate system. When it interacts with clouds, oceans and the sun’s radiation, it has an overall impact on our planet’s living systems, affecting everything from weather and rainfall to global warming.

There are two types of dust in the atmosphere, both kicked up by high-velocity winds in dry areas. Fine dust tends to cool because it scatters sunlight, much like clouds do. Coarse dust, which is larger in size and originates in places like the Sahara Desert, tends to warm the atmosphere, much like greenhouse gases.

Knowing precisely how much coarse dust is in the atmosphere is essential for understanding not only the atmospheric phenomena that dust influences but also the degree to which dust may be warming the planet.

Now, UCLA scientists report that there is four times the amount of coarse dust in Earth’s atmosphere than is currently simulated by climate models. Their findings appear in the journal Science Advances.

The researchers found that Earth’s atmosphere contains 17 million metric tons of coarse dust — equivalent to 17 million elephants or the mass of every person in America put together.

“To properly represent the impact of dust as a whole on the Earth system, climate models must include an accurate treatment of coarse dust in the atmosphere,” said the study’s first author, Adeyemi Adebiyi, a postdoctoral researcher in UCLA’s Department of Atmospheric and Oceanic Sciences and a recipient of the University of California President’s Postdoctoral Fellowship.

By plugging this amount of missing coarse dust into models, Adebiyi said, it increases the likelihood that the net amount of dust overall — both fine and coarse — is warming rather than cooling the Earth’s climate system, from air to oceans.

Coarse dust particles warm the Earth’s entire climate system by absorbing both incoming radiation from the sun and outgoing radiation from the Earth’s surface. These particles can impact stability and circulation within our atmosphere, which may affect atmospheric phenomena like hurricanes.

Adebiyi worked with Jasper Kok, a UCLA associate professor of atmospheric and oceanic sciences, to determine the actual amount of coarse dust in the atmosphere by analyzing dozens of published aircraft-based observations, including recent measurements taken over the Sahara Desert, and comparing those with half a dozen widely used global atmospheric model simulations.

“When we compared our results with what is predicted by current climate models, we found a drastic difference,” Kok said. “State-of-the-art climate models account for only 4 million metric tons, but our results showed more than four times that amount.”

In addition, Adebiyi and Kok found that coarse dust leaves the atmosphere less quickly than current climate models predict. Air has a tendency to mix more turbulently when dust is present. In the case of the Sahara, air and dust mix in ways that push the dust upward, which can work against gravity and keep the dust in the air much longer, they said.

The scientists’ findings also show that because dust particles stay in the atmosphere longer, they are ultimately deposited further from their source than has been predicted by these models or explained by current theory. Dust particles blown from the Sahara, for example, can travel thousands of miles in the atmosphere, reaching as far as the Caribbean and the United States.

When desert dust ends up in oceans, it may stimulate the productivity of ocean ecosystems and increase the amount of carbon dioxide absorbed by the oceans.

Due to the way coarse dust interacts with the sun’s energy and clouds, it can also have a major impact on the timing of precipitation, as well as how much, or how little, rain falls.

“Models have been an invaluable tool for scientists,” said Adebiyi, “but when they miss most of the coarse dust in the atmosphere, it underestimates the impact that this type of dust has on critical aspects of life on Earth, from precipitation to cloud cover to ocean ecosystems to global temperature.”

This article originally appeared in the UCLA Newsroom.

A photo of a valley oak tree.

UCLA College Celebrates Earth Day

A photo of a Griffith Park vista; the view of the Los Angeles skyline from Griffith Park.

Los Angeles County is home to more than 4,000 distinct species of plants and animals, and the sustainability plan aims for “no loss of native biodiversity.” (Photo Credit: Jake Dobkin)

Not only does this mark its 50th anniversary, this Earth Day is unlike any other we have seen as the global pandemic continues to impact the way we live our lives. Yes, it has disrupted our daily routines but it has also benefited the environment in myriad ways. For example, freeways once clogged with traffic have opened up, clearing the air and making way for bright blue skies and views for miles. Even before COVID-19, UCLA College faculty members and teams were out in the field and in their labs, working on groundbreaking research and advising on county and statewide plans. In honor of Earth Day, we are highlighting stories about conservation, sustainability, global warming, solar geoengineering and protecting our precious ecosystems.

 

A photo of vegetation and mountains in California's Anza-Borrego State Park.

Vegetation and mountains in California’s Anza-Borrego State Park. (Photo Credit: Sean Brenner/UCLA)

UCLA to lead $10 million California conservation project

UCLA scientists are leading a $10 million project to help California officials make ecologically wise decisions as the state continues to confront the effects of climate change. The initiative will give California officials scientific data they can use to make decisions about conserving the state’s ecosystems.

A photo of a valley oak tree.

The valley oak, the largest oak in California, grows to over 100 feet tall and provides habitat and food for a variety of animals. (Photo Credit: Victoria Sork/UCLA)

One of California’s iconic tree species offers lessons for conservation

New research led by UCLA evolutionary biologist Victoria Sork examines whether the trees being replanted in the wake of California’s fires will be able to survive a climate that is continuing to warm. The study, which is published in the Proceedings of the Natural Academy of Sciences, focuses on California’s iconic valley oak.

A photo of a Griffith Park vista; the view of the Los Angeles skyline from Griffith Park.

Los Angeles County is home to more than 4,000 distinct species of plants and animals, and the sustainability plan aims for “no loss of native biodiversity.” (Photo Credit: Jake Dobkin)

L.A. County taps UCLA to help create first-ever sustainability plan

The Los Angeles County Board of Supervisors unanimously approved an ambitious sustainability plan that calls for phasing out fossil fuels to address climate change and improve quality of life in the region. Sixteen UCLA researchers contributed to the OurCounty plan, which was created by the county’s Chief Sustainability Office.

A photo of the Santa Monica Pier at night.

The Santa Monica Pier at night. Artificial light can cause problems for a range of species that live and breed in coastal environments. (Photo Credit: William Chen/Pexels)

Study draws Southern California coastal light pollution into focus

Artificial light is known to disrupt mating cycles in species along the Southern California coast. A team of UCLA and University of Southern California researchers led by Travis Longcore, UCLA adjunct professor of urban conservation biology, has mapped light pollution conditions that will be used to inform decisions about future infrastructure and construction plans.

A photo of members of the UCLA Center for Diverse Leadership in Science, which was founded by Aradhna Tripati, associate professor in the UCLA Institute of the Environment and Sustainability.

Members of the Center for Diverse Leadership in Science, which was founded by Professor Aradhna Tripati, third row, far right, and their colleagues. (Photo: Courtesy of Aradhna Tripati)

Professor pays it forward by promoting diversity and environmental justice

When she was appointed in 2009, Aradhna Tripati was the first woman of color out of 50 faculty in UCLA’s Institute of the Environment and Sustainability. Along with colleagues in UCLA’s Anthropology department and American Indian Studies Center, she conducts community engaged research on water in the context of global warming in the southwestern United States. She also formed the first university-based center for diversity in environmental science, with the goal of inspiring a generation of leaders that matches the demographics of the U.S. population.

Andrea Bertozzi (Photo Credit: Courtesy of Andrea Bertozzi)

Mathematics professors earn NSF grant to calculate COVID-19 transmission rates

A photo of Andrea Bertozzi

Andrea Bertozzi (Photo Credit: Courtesy of Andrea Bertozzi)

Uncertainty about COVID-19 transmission rates has been one of the major challenges for health care systems in the United States and around the world.

UCLA mathematics professors Andrea Bertozzi and Mason Porter will use mathematical modeling, incorporating the specific features of COVID-19, to provide insights to those who are developing strategies to mitigate the spread of the disease.

Bertozzi and Porter have been awarded a $200,000 rapid-response research grant from the National Science Foundation, which has called for proposals with the potential to address the spread of COVID-19.

Many public health and infectious disease experts believe the actual transmission of COVID-19 is likely much higher than what has been publicly reported. The UCLA project will extend prior research on contagions, factoring in multiple transmission methods, human behavior patterns, current data and more. It also will provide training for a postdoctoral scholar, a doctoral student and two undergraduates.

Bertozzi and her research team have already published a preprint of a research paper on the challenges of modeling and forecasting the spread of COVID-19, and she and Porter are conducting research on another related paper as part of the project.

Bertozzi holds UCLA’s Betsy Wood Knapp Chair for Innovation and Creativity.

The award is co-funded by NSF programs in applied mathematics and computational mathematics and its office of multidisciplinary activities.

This article originally appeared in the UCLA Newsroom.

 

A photo of Professor Neil Garg

How did organic chemistry become so beloved at UCLA? Professor Neil Garg is glad you asked

People who don’t know Neil Garg may be shocked to learn he has made organic chemistry — the chemistry of molecules made of carbon — one of UCLA’s most beloved and popular undergraduate courses. Students wait for years to get into his class and do celebratory dances when they learn they’re enrolled.

Garg, the Kenneth N. Trueblood Professor of Chemistry and Biochemistry, recently explained how he made the subject so popular and shared some of his teaching techniques in an article published in the Journal of Biological Chemistry. In 2018, Garg became the recipient of the country’s premier university teaching award, the Robert Foster Cherry Award for Great Teaching, given once every two years by Baylor University.

His undergraduate course Chemistry 14D, “Organic Reactions and Pharmaceuticals,” is very demanding. On exams, he asks students — mostly second-year, non-chemistry majors — to solve difficult problems he did not learn to solve until his first year of graduate school at Caltech. Students, for example, are asked to create a reasonable chemical synthesis of molecules they have never seen before. By the end of his course, more than two-thirds of the class can solve these problems.

A photo of Professor Neil Garg

Neil Garg reveals the teaching techniques that helped him to win the country’s premier university teaching award. (Photo Credit: Coral von Zumwalt)

“What is also striking,” Garg writes, “is that the students show impeccable creativity in their solutions, often providing reasonable responses that bear no resemblance to what is shown on the answer key, earning full credit. … My goal is always for students to do extraordinary things and learn to solve the hardest problems I can offer.”

In student surveys about Chemistry 14D more than two-thirds of the students rate their interest in organic chemistry as high, and fewer than 4% rate their interest in the subject as low. This is a dramatic shift from the start of the course when fewer than 10% reported a high rating, and more than 60% reported their interest as low.

In the article, Garg, who is also chair of UCLA’s department of chemistry and biochemistry, but not currently teaching organic chemistry, offers more than a dozen tips for teaching complex science. Among his practices:

-It’s essential to explain the relevance of organic chemistry to students and focus the class on problem-solving, critical thinking and creativity, rather than memorization. He teaches students that for each chemical reaction, there is a logic associated with how and why the reaction takes place. One of his students said she feels “like Sherlock Holmes when solving retrosynthesis problems.”

-He and his teaching assistants continually show students how much they care. Former student Elizabeth Matusov said, “He feels like a friend who happens to be teaching a really difficult class. He’s easily the best professor I’ve ever had. I would take any class with him. We all would.”

-He learns students’ names and calls on them by name, even in a class with 400 students. He stays in touch with hundreds of his former students, including some from 20 years ago.

-He teaches the fundamental vocabulary of organic chemistry and the rules of chemical reactivity, and performs in-class demonstrations with students.

-He poses questions that students answer with clickers, so he can immediately learn what they understand and what concepts require further explanation.

-More than 1,300 of his students have teamed up to make hundreds of music videos that have been viewed around the world hundreds of thousands of times. Many of the best are in Garg’s Chemistry 14D Music Video Hall of Fame, which features such student classics as “I Will Survive,” “Alkenes Are Used for These,” “Chem 14 Dreams Mashup” and “Say Alkane.” While teaching a semester at Baylor University last year, his undergraduate students teamed up to create 37 videos, including a chemistry adaptation of ABBA’s “Dancing Queen.”

-He has created educational resources for students, including BACON (Biology And Chemistry Online Notes), a set of fun and engaging online tutorials that make connections between organic chemistry and sports, health, genetics and popular television shows, among other topics. Other chemistry resources that are free and being used worldwide are a smartphone app called “Backside Attack” that teaches organic chemistry concepts; qrchem.net; and rschemistry.com. QR Chem, a molecule visualization app created by Garg and some of his UCLA students, is being used in more than 160 countries.

Summing up his teaching philosophy, Garg asks, “How did organic chemistry become one of UCLA’s most popular classes? Teaching is all about the students. We must challenge them, support them, make them feel connected to the class and give them opportunities to do amazing things.”

In an acknowledgment at the end of the article, Garg thanks, among others, his “thousands of inspiring students.”

Garg and his family live in a campus residence hall as part of UCLA’s faculty-in-residence program, which allows him to dine with students, advise them, go on trips with them and inspire them daily with his passion for chemistry.

This article originally appeared in the UCLA Newsroom.