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Study shows how serotonin and a popular anti-depressant affect the gut’s microbiota

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Senior author Elaine Hsiao says researchers hope to build on their current study to learn whether microbial interactions with antidepressants have consequences for health and disease. Photo: Reed Hutchinson/UCLA

A new study in mice led by UCLA biologists strongly suggests that serotonin and drugs that target serotonin, such as anti-depressants, can have a major effect on the gut’s microbiota — the 100 trillion or so bacteria and other microbes that live in the human body’s intestines.

Serotonin — a neurotransmitter, or chemical messenger that sends messages among cells — serves many functions in the human body, including playing a role in emotions and happiness. An estimated 90% of the body’s serotonin is produced in the gut, where it influences gut immunity.

The team — led by senior author Elaine Hsiao and lead author Thomas Fung, a postdoctoral fellow — identified a specific gut bacterium that can detect and transport serotonin into bacterial cells. When mice were given the antidepressant fluoxetine, or Prozac, the biologists found this reduced the transport of serotonin into their cells. This bacterium, about which little is known, is called Turicibacter sanguinis. The study is published this week in the journal Nature Microbiology.

“Our previous work showed that particular gut bacteria help the gut produce serotonin. In this study, we were interested in finding out why they might do so,” said Hsiao, UCLA assistant professor of integrative biology and physiology, and of microbiology, immunology and molecular genetics in the UCLA College; and of digestive diseases in the David Geffen School of Medicine at UCLA.

Hsiao and her research group reported in the journal Cell in 2015 that in mice, a specific mixture of bacteria, consisting mainly of Turicibacter sanguinis and Clostridia, produces molecules that signal to gut cells to increase production of serotonin. When Hsiao’s team raised mice without the bacteria, more than 50% of their gut serotonin was missing. The researchers then added the bacteria mixture of mainly Turicibacter and Clostridia, and their serotonin increased to a normal level.

That study got the team wondering why bacteria signal to our gut cells to make serotonin. Do microbes use serotonin, and if so, for what?

In this new study, the researchers added serotonin to the drinking water of some mice and raised others with a mutation (created by altering a specific serotonin transporter gene) that increased the levels of serotonin in their guts. After studying the microbiota of the mice, the researchers discovered that the bacteria Turicibacter and Clostridia increased significantly when there was more serotonin in the gut.

If these bacteria increase in the presence of serotonin, perhaps they have some cellular machinery to detect serotonin, the researchers speculated. Together with study co-author Lucy Forrest and her team at the National Institutes of Health’s National Institute of Neurological Disorders and Stroke, the researchers found a protein in multiple species of Turicibacter that has some structural similarity to a protein that transports serotonin in mammals. When they grew Turicibacter sanguinis in the lab, they found that the bacterium imports serotonin into the cell.

In another experiment, the researchers added the antidepressant fluoxetine, which normally blocks the mammalian serotonin transporter, to a tube containing Turicibacter sanguinis. They found the bacterium transported significantly less serotonin.

The team found that exposing Turicibacter sanguinis to serotonin or fluoxetine influenced how well the bacterium could thrive in the gastrointestinal tract. In the presence of serotonin, the bacterium grew to high levels in mice, but when exposed to fluoxetine, the bacterium grew to only low levels in mice.

“Previous studies from our lab and others showed that specific bacteria promote serotonin levels in the gut,” Fung said. “Our new study tells us that certain gut bacteria can respond to serotonin and drugs that influence serotonin, like anti-depressants. This is a unique form of communication between bacteria and our own cells through molecules traditionally recognized as neurotransmitters.”

The team’s research on Turicibacter aligns with a growing number of studies reporting that anti-depressants can alter the gut microbiota. “For the future,” Hsiao said, “we want to learn whether microbial interactions with antidepressants have consequences for health and disease.” Hsiao wrote a blog post for the journal about the new research.

Other study co-authors are Helen Vuong, Geoffrey Pronovost, Cristopher Luna, Anastasia Vavilina, Julianne McGinn and Tomiko Rendon, all of UCLA; and Antoniya Aleksandrova and Noah Riley, members of Forrest’s team.

The research was supported by funding from the National Institutes of Health’s Director’s Early Independence Award, Klingenstein-Simons Fellowship Award, and David & Lucile Packard Foundation’s Packard Fellowship for Science and Engineering.

This article originally appeared in the UCLA Newsroom.

Biochemists discover new insights into what may go awry in brains of people with Alzheimer’s

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Photo of two researchers in lab.

Research by UCLA professor Steven Clarke and former graduate student Rebeccah Warmack, as well as UCLA colleagues, reveals new information about the brain’s biochemistry.

More than three decades of research on Alzheimer’s disease have not produced any major treatment advances for those with the disorder, according to a UCLA expert who has studied the biochemistry of the brain and Alzheimer’s for nearly 30 years. “Nothing has worked,” said Steven Clarke, a distinguished professor of chemistry and biochemistry. “We’re ready for new ideas.” Now, Clarke and UCLA colleagues have reported new insights that may lead to progress in fighting the devastating disease.

Scientists have known for years that amyloid fibrils — harmful, elongated, water-tight rope-like structures — form in the brains of people with Alzheimer’s, and likely hold important clues to the disease. UCLA Professor David Eisenberg and an international team of chemists and molecular biologists reported in the journal Nature in 2005 that amyloid fibrils contain proteins that interlock like the teeth of a zipper. The researchers also reported their hypothesis that this dry molecular zipper is in the fibrils that form in Alzheimer’s disease, as well as in Parkinson’s disease and two dozen other degenerative diseases. Their hypothesis has been supported by recent studies.

Alzheimer’s disease, the most common cause of dementia among older adults, is an irreversible, progressive brain disorder that kills brain cells, gradually destroys memory and eventually affects thinking, behavior and the ability to carry out the daily tasks of life. More than 5.5 million Americans, most of whom are over 65, are thought to have dementia caused by Alzheimer’s.

The UCLA team reports in the journal Nature Communications that the small protein beta amyloid, also known as a peptide, that plays an important role in Alzheimer’s has a normal version that may be less harmful than previously thought and an age-damaged version that is more harmful.

Rebeccah Warmack, who was a UCLA graduate student at the time of the study and is its lead author, discovered that a specific version of age-modified beta amyloid contains a second molecular zipper not previously known to exist. Proteins live in water, but all the water gets pushed out as the fibril is sealed and zipped up. Warmack worked closely with UCLA graduate students David Boyer, Chih-Te Zee and Logan Richards; as well as senior research scientists Michael Sawaya and Duilio Cascio.

What goes wrong with beta amyloid, whose most common forms have 40 or 42 amino acids that are connected like a string of beads on a necklace?

The researchers report that with age, the 23rd amino acid can spontaneously form a kink, similar to one in a garden hose. This kinked form is known as isoAsp23. The normal version does not create the stronger second molecular zipper, but the kinked form does.

“Now we know a second water-free zipper can form, and is extremely difficult to pry apart,” Warmack said. “We don’t know how to break the zipper.”

The normal form of beta amyloid has six water molecules that prevent the formation of a tight zipper, but the kink ejects these water molecules, allowing the zipper to form.

When one of its amino acids forms a kink, beta amyloid creates a harmful molecular zipper, shown here in green. Photo credit: Rebeccah Warmack/UCLA

When one of its amino acids forms a kink, beta amyloid creates a harmful molecular zipper, shown here in green.
“Rebeccah has shown this kink leads to faster growth of the fibrils that have been linked to Alzheimer’s disease,” said Clarke, who has conducted research on biochemistry of the brain and Alzheimer’s disease since 1990. “This second molecular zipper is double trouble. Once it’s zipped, it’s zipped, and once the formation of fibrils starts, it looks like you can’t stop it. The kinked form initiates a dangerous cascade of events that we believe can result in Alzheimer’s disease.”

Why does beta amyloid’s 23rd amino acid sometimes form this dangerous kink?

Clarke thinks the kinks in this amino acid form throughout our lives, but we have a protein repair enzyme that fixes them.

“As we get older, maybe the repair enzyme misses the repair once or twice,” he said. “The repair enzyme might be 99.9% effective, but over 60 years or more, the kinks eventually build up. If not repaired or if degraded in time, the kink can spread to virtually every neuron and can do tremendous damage.”

“The good news is that knowing what the problem is, we can think about ways to solve it,” he added. “This kinked amino acid is where we want to look.”

The research offers clues to pharmaceutical companies, which could develop ways to prevent formation of the kink or get the repair enzyme to work better; or by designing a cap that would prevent fibrils from growing.

Clarke said beta amyloid and a much larger protein tau — with more than 750 amino acids — make a devastating one-two punch that forms fibrils and spreads them to many neurons throughout the brain. All humans have both beta amyloid and tau. Researchers say it appears that beta amyloid produces fibrils that can lead to tau aggregates, which can spread the toxicity to other brain cells. However, exactly how beta amyloid and tau work together to kill neurons is not yet known.

In this study, Warmack produced crystals, both the normal and kinked types, in 15 of beta amyloid’s amino acids. She used a modified type of cryo-electron microscopy to analyze the crystals. Cryo-electron microscopy, whose development won its creators the 2017 Nobel Prize in chemistry, enables scientists to see large biomolecules in extraordinary detail. Professor Tamir Gonen pioneered the modified microscopy, called microcrystal electron diffraction, which enables scientists to study biomolecules of any size.

Eisenberg is UCLA’s Paul D. Boyer Professor of Molecular Biology and a Howard Hughes Medical Institute investigator. Other researchers are co-author Gonen, a professor of biological chemistry and physiology at the UCLA David Geffen School of Medicine and a Howard Hughes Medical Institute investigator; and Jose Rodriguez, assistant professor of chemistry and biochemistry who holds the Howard Reiss Career Development Chair.

The research was funded by the National Science Foundation, National Institutes of Health, Howard Hughes Medical Institute, and the UCLA Longevity Center’s Elizabeth and Thomas Plott Chair in Gerontology, which Clarke held for five years.

This article originally appeared in the UCLA Newsroom.

Photo of artist rendering of SO-2 star.

Einstein’s general relativity theory is questioned but still stands ‘for now,’ team reports

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Photo of artist rendering of SO-2 star.

A star known as S0-2 (the blue and green object in this artist’s rendering) made its closest approach to the supermassive black hole at the center of the Milky Way in 2018. Artist’s rendering by Nicolle Fuller/National Science Foundation.

More than 100 years after Albert Einstein published his iconic theory of general relativity, it is beginning to fray at the edges, said Andrea Ghez, UCLA professor of physics and astronomy. Now, in the most comprehensive test of general relativity near the monstrous black hole at the center of our galaxy, Ghez and her research team report July 25 in the journal Science that Einstein’s theory of general relativity holds up.

“Einstein’s right, at least for now,” said Ghez, a co-lead author of the research. “We can absolutely rule out Newton’s law of gravity. Our observations are consistent with Einstein’s theory of general relativity. However, his theory is definitely showing vulnerability. It cannot fully explain gravity inside a black hole, and at some point we will need to move beyond Einstein’s theory to a more comprehensive theory of gravity that explains what a black hole is.”

Einstein’s 1915 theory of general relativity holds that what we perceive as the force of gravity arises from the curvature of space and time. The scientist proposed that objects such as the sun and the Earth change this geometry. Einstein’s theory is the best description of how gravity works, said Ghez, whose UCLA-led team of astronomers has made direct measurements of the phenomenon near a supermassive black hole — research Ghez describes as “extreme astrophysics.”

The laws of physics, including gravity, should be valid everywhere in the universe, said Ghez, who added that her research team is one of only two groups in the world to watch a star known as S0-2 make a complete orbit in three dimensions around the supermassive black hole at the center of the Milky Way. The full orbit takes 16 years, and the black hole’s mass is about 4 million times that of the sun.

The researchers say their work is the most detailed study ever conducted into the supermassive black hole and Einstein’s theory of general relativity.

The key data in the research were spectra that Ghez’s team analyzed last April, May and September as her “favorite star” made its closest approach to the enormous black hole. Spectra, which Ghez described as the “rainbow of light” from stars, show the intensity of light and offer important information about the star from which the light travels. Spectra also show the composition of the star. These data were combined with measurements Ghez and her team have made over the last 24 years.

Spectra — collected at the W.M. Keck Observatory in Hawaii using a spectrograph built at UCLA by a team led by colleague James Larkin — provide the third dimension, revealing the star’s motion at a level of precision not previously attained. (Images of the star the researchers took at the Keck Observatory provide the two other dimensions.) Larkin’s instrument takes light from a star and disperses it, similar to the way raindrops disperse light from the sun to create a rainbow, Ghez said.

“What’s so special about S0-2 is we have its complete orbit in three dimensions,” said Ghez, who holds the Lauren B. Leichtman and Arthur E. Levine Chair in Astrophysics. “That’s what gives us the entry ticket into the tests of general relativity. We asked how gravity behaves near a supermassive black hole and whether Einstein’s theory is telling us the full story. Seeing stars go through their complete orbit provides the first opportunity to test fundamental physics using the motions of these stars.”

Ghez’s research team was able to see the co-mingling of space and time near the supermassive black hole. “In Newton’s version of gravity, space and time are separate, and do not co-mingle; under Einstein, they get completely co-mingled near a black hole,” she said.

“Making a measurement of such fundamental importance has required years of patient observing, enabled by state-of-the-art technology,” said Richard Green, director of the National Science Foundation’s division of astronomical sciences. For more than two decades, the division has supported Ghez, along with several of the technical elements critical to the research team’s discovery. “Through their rigorous efforts, Ghez and her collaborators have produced a high-significance validation of Einstein’s idea about strong gravity.”

Keck Observatory Director Hilton Lewis called Ghez “one of our most passionate and tenacious Keck users.” “Her latest groundbreaking research,” he said, “is the culmination of unwavering commitment over the past two decades to unlock the mysteries of the supermassive black hole at the center of our Milky Way galaxy.”

The researchers studied photons — particles of light — as they traveled from S0-2 to Earth. S0-2 moves around the black hole at blistering speeds of more than 16 million miles per hour at its closest approach. Einstein had reported that in this region close to the black hole, photons have to do extra work. Their wavelength as they leave the star depends not only on how fast the star is moving, but also on how much energy the photons expend to escape the black hole’s powerful gravitational field. Near a black hole, gravity is much stronger than on Earth.

Ghez was given the opportunity to present partial data last summer, but chose not to so that her team could thoroughly analyze the data first. “We’re learning how gravity works. It’s one of four fundamental forces and the one we have tested the least,” she said. “There are many regions where we just haven’t asked, how does gravity work here? It’s easy to be overconfident and there are many ways to misinterpret the data, many ways that small errors can accumulate into significant mistakes, which is why we did not rush our analysis.”

Ghez, a 2008 recipient of the MacArthur “Genius” Fellowship, studies more than 3,000 stars that orbit the supermassive black hole. Hundreds of them are young, she said, in a region where astronomers did not expect to see them.

It takes 26,000 years for the photons from S0-2 to reach Earth. “We’re so excited, and have been preparing for years to make these measurements,” said Ghez, who directs the UCLA Galactic Center Group. “For us, it’s visceral, it’s now — but it actually happened 26,000 years ago!”

This is the first of many tests of general relativity Ghez’s research team will conduct on stars near the supermassive black hole. Among the stars that most interest her is S0-102, which has the shortest orbit, taking 11 1/2 years to complete a full orbit around the black hole. Most of the stars Ghez studies have orbits of much longer than a human lifespan.

Ghez’s team took measurements about every four nights during crucial periods in 2018 using the Keck Observatory — which sits atop Hawaii’s dormant Mauna Kea volcano and houses one of the world’s largest and premier optical and infrared telescopes. Measurements are also taken with an optical-infrared telescope at Gemini Observatory and Subaru Telescope, also in Hawaii. She and her team have used these telescopes both on site in Hawaii and remotely from an observation room in UCLA’s department of physics and astronomy.

Black holes have such high density that nothing can escape their gravitational pull, not even light. (They cannot be seen directly, but their influence on nearby stars is visible and provides a signature. Once something crosses the “event horizon” of a black hole, it will not be able to escape. However, the star S0-2 is still rather far from the event horizon, even at its closest approach, so its photons do not get pulled in.)

Photo of telescope pointing to the sky.

Lasers from the two Keck telescopes point in the direction of the center of our galaxy. Each laser creates an “artificial star” that astronomers can use to correct for the blurring caused by the Earth’s atmosphere. Photo: Ethan Tweedie

Ghez’s co-authors include Tuan Do, lead author of the Science paper, a UCLA research scientist and deputy director of the UCLA Galactic Center Group; Aurelien Hees, a former UCLA postdoctoral scholar, now a researcher at the Paris Observatory; Mark Morris, UCLA professor of physics and astronomy; Eric Becklin, UCLA professor emeritus of physics and astronomy; Smadar Naoz, UCLA assistant professor of physics and astronomy; Jessica Lu, a former UCLA graduate student who is now a UC Berkeley assistant professor of astronomy; UCLA graduate student Devin Chu; Greg Martinez, UCLA project scientist; Shoko Sakai, a UCLA research scientist; Shogo Nishiyama, associate professor with Japan’s Miyagi University of Education; and Rainer Schoedel, a researcher with Spain’s Instituto de Astrofısica de Andalucıa.

The National Science Foundation has funded Ghez’s research for the last 25 years. More recently, her research has also been supported by the W.M. Keck Foundation, the Gordon and Betty Moore Foundation and the Heising-Simons Foundation; as well as Lauren Leichtman and Arthur Levine, and Howard and Astrid Preston.

In 1998, Ghez answered one of astronomy’s most important questions, helping to show that a supermassive black hole resides at the center of our Milky Way galaxy. The question had been a subject of much debate among astronomers for more than a quarter of a century.

A powerful technology that Ghez helped to pioneer, called adaptive optics, corrects the distorting effects of the Earth’s atmosphere in real time. With adaptive optics at Keck Observatory, Ghez and her colleagues have revealed many surprises about the environments surrounding supermassive black holes. For example, they discovered young stars where none was expected to be seen and a lack of old stars where many were anticipated. It’s unclear whether S0-2 is young or just masquerading as a young star, Ghez said.

In 2000, she and colleagues reported that for the first time, astronomers had seen stars accelerate around the supermassive black hole. In 2003, Ghez reported that the case for the Milky Way’s black hole had been strengthened substantially and that all of the proposed alternatives could be excluded.

In 2005, Ghez and her colleagues took the first clear picture of the center of the Milky Way, including the area surrounding the black hole, at Keck Observatory. And in 2017, Ghez’s research team reported that S0-2 does not have a companion star, solving another mystery.

This article originally appeared in the UCLA Newsroom.

Physical Sciences Dean Miguel García-Garibay has been elected a 2019 Fellow of the American Chemical Society

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Photo of Miguel García-Garibay

Miguel García-Garibay, Dean of the UCLA College Division of Physical Sciences.

Miguel García-Garibay, dean of the UCLA Division of Physical Sciences and professor of chemistry and biochemistry, has been elected a 2019 fellow of the American Chemical Society, the ACS announced.

García-Garibay is a pioneer in research on molecular motion in crystals, molecular machines and green chemistry.

He has earned worldwide recognition in the fields of organic photochemistry, solid-state organic chemistry and physical organic chemistry. García-Garibay studies the interaction of light and molecules in crystals. Light can have enough energy to break and make bonds in molecules, and his research team has shown that crystals offer an opportunity to control the outcome of these chemical reactions. He is interested in the basic science of molecules in crystals.

His research has applications for green chemistry that may lead to the production of specialty chemicals that would be very difficult to produce by traditional methods due to their complex structures, as well as applications for molecular electronics and miniaturized devices. His research group has made advances in the field of artificial molecular machines and amphidynamic crystals, a term García-Garibay invented, referring to crystals built with molecules that have a combination of static and mobile components. His research is funded by the National Science Foundation, among other funding sources.

“I can get a precise picture of the molecules in the crystals, the precise arrangement of atoms, with almost no uncertainty,” García-Garibay said. “This provides a large level of control, which enables us to learn the different principles governing molecular functions at the nanoscale.”

He has won many honors for his research, including selection as a fellow of the American Association for the Advancement of Science, as well as numerous honors from the National Science Foundation and the American Chemical Society. He is a member of the California NanoSystems Institute and the Society for Advancement of Chicanos/Hispanics and Native Americans in Science, among other scholarly organizations.

ACS fellows are nominated by their peers and selected for their outstanding accomplishments in scientific research, education and public service. The 2019 fellows will be honored at a ceremony during the ACS national meeting in San Diego on Aug. 26.

This story originally appeared here.

4d graphic rendering of iron-platinum nanoparticle

Atomic motion is captured in 4D for the first time

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4d graphic rendering of iron-platinum nanoparticle

The image shows 4D atomic motion captured in an iron-platinum nanoparticle at three different times.
Credit: Alexander Tokarev

Results of UCLA-led study contradict a long-held classical theory

Everyday transitions from one state of matter to another — such as freezing, melting or evaporation — start with a process called “nucleation,” in which tiny clusters of atoms or molecules (called “nuclei”) begin to coalesce. Nucleation plays a critical role in circumstances as diverse as the formation of clouds and the onset of neurodegenerative disease.

A UCLA-led team has gained a never-before-seen view of nucleation — capturing how the atoms rearrange at 4D atomic resolution (that is, in three dimensions of space and across time). The findings, published in the journal Nature, differ from predictions based on the classical theory of nucleation that has long appeared in textbooks.

“This is truly a groundbreaking experiment — we not only locate and identify individual atoms with high precision, but also monitor their motion in 4D for the first time,” said senior author Jianwei “John” Miao, a UCLA professor of physics and astronomy, who is the deputy director of the STROBE National Science Foundation Science and Technology Center and a member of the California NanoSystems Institute at UCLA.

Research by the team, which includes collaborators from Lawrence Berkeley National Laboratory, University of Colorado at Boulder, University of Buffalo and the University of Nevada, Reno, builds upon a powerful imaging techniquepreviously developed by Miao’s research group. That method, called “atomic electron tomography,” uses a state-of-the-art electron microscope located at Berkeley Lab’s Molecular Foundry, which images a sample using electrons. The sample is rotated, and in much the same way a CAT scan generates a three-dimensional X-ray of the human body, atomic electron tomography creates stunning 3D images of atoms within a material.

Miao and his colleagues examined an iron-platinum alloy formed into nanoparticles so small that it takes more than 10,000 laid side by side to span the width of a human hair. To investigate nucleation, the scientists heated the nanoparticles to 520 degrees Celsius, or 968 degrees Fahrenheit, and took images after 9 minutes, 16 minutes and 26 minutes. At that temperature, the alloy undergoes a transition between two different solid phases.

Although the alloy looks the same to the naked eye in both phases, closer inspection shows that the 3D atomic arrangements are different from one another. After heating, the structure changes from a jumbled chemical state to a more ordered one, with alternating layers of iron and platinum atoms. The change in the alloy can be compared to solving a Rubik’s Cube — the jumbled phase has all the colors randomly mixed, while the ordered phase has all the colors aligned.

In a painstaking process led by co-first authors and UCLA postdoctoral scholars Jihan Zhou and Yongsoo Yang, the team tracked the same 33 nuclei — some as small as 13 atoms — within one nanoparticle.

“People think it’s difficult to find a needle in a haystack,” Miao said. “How difficult would it be to find the same atom in more than a trillion atoms at three different times?”

The results were surprising, as they contradict the classical theory of nucleation. That theory holds that nuclei are perfectly round. In the study, by contrast, nuclei formed irregular shapes. The theory also suggests that nuclei have a sharp boundary. Instead, the researchers observed that each nucleus contained a core of atoms that had changed to the new, ordered phase, but that the arrangement became more and more jumbled closer to the surface of the nucleus.

Classical nucleation theory also states that once a nucleus reaches a specific size, it only grows larger from there. But the process seems to be far more complicated than that: In addition to growing, nuclei in the study shrunk, divided and merged; some dissolved completely.

“Nucleation is basically an unsolved problem in many fields,” said co-author Peter Ercius, a staff scientist at the Molecular Foundry, a nanoscience facility that offers users leading-edge instrumentation and expertise for collaborative research. “Once you can image something, you can start to think about how to control it.”

The findings offer direct evidence that classical nucleation theory does not accurately describe phenomena at the atomic level. The discoveries about nucleation may influence research in a wide range of areas, including physics, chemistry, materials science, environmental science and neuroscience.

“By capturing atomic motion over time, this study opens new avenues for studying a broad range of material, chemical and biological phenomena,” said National Science Foundation program officer Charles Ying, who oversees funding for the STROBE center. “This transformative result required groundbreaking advances in experimentation, data analysis and modeling, an outcome that demanded the broad expertise of the center’s researchers and their collaborators.”

Other authors were Yao Yang, Dennis Kim, Andrew Yuan and Xuezeng Tian, all of UCLA; Colin Ophus and Andreas Schmid of Berkeley Lab; Fan Sun and Hao Zeng of the University at Buffalo in New York; Michael Nathanson and Hendrik Heinz of the University of Colorado at Boulder; and Qi An of the University of Nevada, Reno.

The research was primarily supported by the STROBE National Science Foundation Science and Technology Center, and also supported by the U.S. Department of Energy.

This story originally appeared in the UCLA Newsroom.

Space physicist wins Royal Astronomical Society 2019 Gold Medal

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Margaret Kivelson, who discovered an ocean inside Jupiter’s moon Europa and a magnetic field generated by neighboring Ganymede, has been awarded the Royal Astronomical Society’s 2019 Gold Medal.

Photo of the UCLA team that built two NASA satellites to study space weather

UCLA students launch project that’s out of this world

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Photo of the UCLA team that built two NASA satellites to study space weather

UCLA aims to be one of the few universities to ever complete such a sophisticated space science mission — designed and built by students — from beginning to end.

Five years ago, a group of UCLA undergrads came together with a common goal — to build a small satellite and launch it into space. In the years since, more than 250 students — many of whom are now UCLA graduate students and alumni — have been the mechanical engineers, software developers, thermal and power testers, electronics technicians, mission planners and fabricators of the twin Electron Losses and Fields Investigation CubeSats, known as ELFIN.

Although UCLA has been building space instruments for NASA and other international space missions for more than 40 years, and members of its faculty have been critical contributors to space science, ELFIN is the first satellite mission built, managed and operated entirely at UCLA. And even more impressive, just about all of it has been done by the students.

This week, dozens of ELFINers (a nickname earned by those who’ve worked on the satellites), will drive about 150 miles up the California coast from Los Angeles to Vandenberg Air Force Base near Lompoc, to watch the product of their effort ascend into orbit.

“Just seeing all the hundreds of hours of work, that not just myself but others too, have put into this project, the many sleepless nights, the stressing out that you’re not going to make a deadline — just seeing it go up there … I’m probably going to cry,” said Jessica Artinger, an astrophysics major and geophysics and planetary science minor who will begin her fifth year this fall.

The two micro-satellites, each weighing about eight pounds and roughly the size of a loaf of bread, will help scientists better understand magnetic storms in near-Earth space. These storms are a typical form of “space weather” that is induced by solar activity, including flares and violent solar eruptions. Some solar outbursts can impact Earth, generating large amounts of invisible electromagnetic energy that transforms our local space environment.

“Magnetic storms are not just interesting space phenomena. They can energize electrons to high energies that can damage or even destroy orbiting satellites we depend on for GPS, communications and weather monitoring,” said Margaret Kivelson, UCLA professor emeritus of space physics. “They can also enhance space electrical currents which flow onto Earth, and could damage the power grid. Space weather research is also crucial for space tourism and space exploration.”

Currently, scientists’ ability to accurately model and predict space weather is in its infancy, just like meteorology was at the turn of the last century. ELFIN will make headway toward better understanding these phenomena.

ELFIN will go up as a secondary payload with the ICESat-2 mission at dawn on Saturday, Sept. 15, aboard the trusted Delta II, the final and hopefully 100th consecutive successful launch of this type of rocket. The launch will be streamed live on NASA TV’s YouTube channel, as well as on UCLA social media (follow #uclaELFIN).

Photo of Jessica Artinger

Jessica Artinger

Following the launch, many ELFINers at Vandenberg will come back to the campus command center to eagerly await the first Bruin transmissions from space, which are expected about 10 hours after blast-off. UCLA students will be directly involved in day-to-day mission activities and will have privileged access to ELFIN’s data. They will track and command the satellite via a custom-built antenna atop Knudsen Hall and will download data directly to the mission operations center located in the Earth, planetary and space sciences department. The ELFIN website will have interactive tools so the public can track and listen to the spacecraft as it passes overhead twice a day. The CubeSats are expected to remain in space for two years, after which they will gradually fall out of orbit and burn up in the atmosphere like shooting stars.

In fall 2017, as head of ELFIN’s fabrication team, Artinger led a small team that worked tirelessly in the EPSS prototyping lab using band saws, drill presses and a CNC machine (which is used to carve and smooth metal parts) to meticulously craft tightly toleranced components to meet their completion deadline.

“There was a lot of working things out in your head before machining it, especially for safety reasons,” said Artinger, who gave a final inspection by painstakingly sanding each part and then re-measuring each and every hole, comparing them to the technical drawings for accuracy before sending them upstairs to the mechanical team for assembly. The aerospace-grade tolerance requirement across the 13.5-inch long spacecraft, she said, was two thousandths of an inch — about half the thickness of a standard sheet of paper. The team also had to machine the sensitive energetic particle detector frames to an incredibly precise 1/10,000 of an inch, she said.

Artinger, a transfer student who graduated from Orange Coast College in 2016, plans to become a community college professor and can’t wait to use her ELFIN experience to inspire a new generation of students. She says ELFIN really opened her eyes to the power of mentoring through research and further solidified her commitment to teaching topics related to space science.

“Maybe we can discover something at the community college I’ll be working at using the actual data from the satellite that I helped build,” she said. “That would be really cool.”

Photo of Ethan Tsai

Ethan Tsai

Ethan Tsai learned about ELFIN when he was a UCLA sophomore. Despite having no background in space science, the former physics major started to work on simple tasks and gained the necessary skills to become the project’s attitude determination and control subsystem lead. Now studying for his master’s in electrical engineering, Tsai is ELFIN’s project manager.

“I was pretty honored to be able to work on a mission like this,” he said, adding that he never imagined being involved in a NASA mission as an undergraduate. “It wasn’t until about two years into the project that I started to understand and appreciate the quality of the work we were doing and how it’s going to actually affect not just our mission and the students around us but the scientific community as a whole.”

Tsai said he’s excited about the infrastructure he has helped create to make UCLA a “space campus,” supporting students who will work on future satellite missions.

The project has been supported with funding from the National Science Foundation and NASA, with technical assistance from the Aerospace Corporation among other industry partners and universities.

Diagram of ELFIN components

CubeSats like ELFIN pack instruments into a loaf-of-bread sized satellite.

Those who have witnessed the aurora borealis and australis illuminate the skies, also known as the northern and southern lights, have experienced the beauty and power of space weather, likely without even knowing it.

“The aurora is sort of a TV screen that shows us what happens out in space.” said Vassilis Angelopoulos, a UCLA space physicist who got his doctorate at UCLA and serves as ELFIN’s principal investigator. “Space physicists can tell if something interesting or important is going on in space by looking at the aurora.”

Photo of Vassilis Angelopoulos

Vassilis Angelopoulos

ELFIN aims to observe the complex sequence whereby magnetic storms form waves near Earth, accelerating and forcing electrons to fall into the atmosphere, while a network of all-sky cameras across North America captures the resulting brightening of the auroral lights. The field of space science benefits from multi-satellite missions like ELFIN because of the ever-growing need to know about the dynamic conditions in space.

“Just like with atmospheric weather,” Angelopoulos said, “you need multiple space weather buoys to feed their data into our space weather models and be able to make predictions of conditions in the future.”

CubeSats fill this need because of their compact size, relative affordability ($300,000 compared to several hundred million dollars for a typical research satellite), and how quickly a team can go from prototyping to launch compared to standard-sized satellites. CubeSats uniquely allow students to witness end-to-end satellite mission development, testing and operations all within the span of their undergraduate studies.

For ELFINers, being part of an endeavor of this magnitude is reward enough, but working on this project also has professional and scientific benefits, Angelopoulos said. In addition to the leadership, interpersonal, problem-solving and technical skills they’ve developed, ELFINers are also contributing to the production of knowledge, something that is incredibly valuable to society and to their careers as scientists and engineers.

Photo of Ethan Tsai working on flight model assembly

Ethan Tsai works on the flight model assembly for the CubeSat ELFIN.

“As a researcher it’s important to not just analyze data that others collect, but to be involved in designing your own unique experiments to explore new key science questions. This is how space science started, with experiments on small rockets where students were involved in the nuts and bolts of them, and similarly with CubeSats, this is where the future of space science education is headed now,” Angelopoulos said.

Building on the opportunities that exist here at UCLA, and knowing the impact that experiential learning can have on a student’s academic life, Angelopoulos wanted to find a way to bring CubeSat development into the undergraduate experience.

“CubeSats are ideal because they create an environment where students from all walks of life, from all disciplines, can come together and practice what they’ve learned during their formal education in the context of a realistic environment,” Angelopoulos said. “This is exactly what academia, industry and research organizations around the country need — and they tell us that. This is the kind of experience they want in people who are applying to graduate school or who are applying to work in industrial firms because these are people who think on their feet and innovate.”

The launch of the UCLA-student-built ELFIN satellites

We have liftoff of student-built satellites

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The launch of the UCLA-student-built ELFIN satellites

The launch of the UCLA-student-built ELFIN satellites aboard a Delta II rocket from Vandenberg Air Force Base at 6:02 a.m. on Saturday, Sept. 15.

 

For the dozens of UCLA students, faculty, staff and alumni braving the chilly temperatures near Vandenberg Air Force Base on Saturday morning, the brilliant ray of white that radiated across the predawn horizon was the best goodbye ever.

At 6:02 a.m. a Delta II rocket lifted off from the base in Lompoc, California, carrying ELFIN — twin micro-satellites, each weighing about eight pounds and roughly the size of a loaf of bread — into orbit aboard NASA’s ICESat-2 mission.

Saturday’s launch was the culmination of years of planning, dreaming, fabricating, designing, assembling, testing and programming, virtually all of it done by more than 250 UCLA students, most of whom were undergraduates.

“It’s really been a very emotional moment for a lot of students here,” said Ethan Tsai, UCLA graduate student in electrical engineering and ELFIN’s project manager. Tsai, more than two dozen other current students, alumni and faculty, including Vassilis Angelopoulos, professor of space physics and ELFIN’s principal investigator, watched from the VIP area.

“There’s half of my brain that’s trying to stick with the professional mode … and then part of me is just like I can’t believe this thing is launching and I can’t believe this thing is in space,” Tsai said. “I don’t know that it’s sunk in yet. But it’s really emotional for me.”

Luis Frausto, 34, a 2010 UCLA mechanical engineering graduate, who worked on early prototypes of ELFIN, said he was in “total awe” watching the launch from a public viewing site near Vandenberg Middle School.

Frausto, now a design engineer at TAE Technologies, Inc., was one of more than 200 (a record for the Vandenberg public viewing site, according to a base spokesman) who braved the chilly temperatures, including about 40 UCLA ELFINers and a few of their friends, who counted down to zero as the launch went off, sending the crowd into cheers and applause.

“You can’t compare it to watching it on TV. It was like a feeling inside my chest, like I was out of breath,” said Frausto, who left his home in Irvine at 12:30 a.m. to drive the 200 miles northwest to Lompoc. “I’m here and I’m honored to be around everyone who worked on ELFIN.”

ELFIN, which stands for Electron Losses and Fields Investigation CubeSats, is designed to help scientists better understand magnetic storms in near-Earth space. These storms are a typical form of “space weather” that is induced by solar activity, including flares and violent solar eruptions. Magnetic storms can result in damage or even destruction of orbiting satellites that humans depend on for GPS, communications and weather monitoring. Space weather research is also crucial for space tourism and space exploration.

Another former ELFINer who came out was Mike Lawson, who works at the Jet Propulsion Laboratory in Pasadena on the Mars 2020 mission. Lawson slept only two hours on a couch at UCLA before he left Westwood at midnight for what he described as an “emotional” drive on U.S. 101 that included listening to David Bowie’s “Starman.”

“It’s weird. It’s surreal. It was 10 years gone in like 20 seconds,” said Lawson, who earned his bachelor’s degree and Ph.D. in geology from UCLA. The 37-year-old was one of the original ELFINers 10 years ago who worked on prototypes for what would become the satellites that launched this morning. Work began five years ago on the actual satellites that went into orbit, aboard NASA’s final Delta II rocket mission.

Jessica Artinger, an astrophysics major who will begin her fifth year at UCLA this fall, left at 1 a.m. from Fountain Valley in Orange County to make the trip. Since fall quarter 2017, Artinger has led the fabrication team.

“Watching this,” said Artinger, who prior to the launch had expected to cry but despite the dry eyes was nevertheless moved, “my time here means something.”

Louise Tamondong, who is part of ELFIN’s flight operations team, said she got chills watching the launch, which was easily visible for just a few seconds before the rocket was shrouded in thick clouds. About 10 seconds after the sky lit up, the crowd finally heard the roar of the rocket’s engines.

“It felt so unreal that everything that we worked for is going into space … it only felt real when we saw that bright light and everything going up,” said Tamondong. After liftoff, she headed back to Westwood to listen for the first signal from the orbiting ELFIN through an antenna on the roof of UCLA’s Knudsen Hall. They received a signal around 4:30 p.m., confirming that both probes survived the bumpy ride to orbit. The team will now begin commissioning the spacecraft systems and instruments to prepare for the science operations phase.

As a new Bruin, Sixue Xu wasn’t part of the team that designed, tested and built ELFIN. But the graduate student in space physics will be among those who stand to benefit from ELFIN’s work.

“Now it’s our turn,” Xu said, “to make that data into science.”

Ph.D. student mixes science and entertainment to unleash a ‘wow’ factor

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For UCLA biochemistry Ph.D. student Jeffrey Vinokur, science is better when shared.

To share his favorite subject broadly, Vinokur leads a dual life as complex as some of the enzymes he is studying. When he’s not looking deep into the structural analysis of mevalonate-3-kinase in the quiet of his lab, he’s a nationally known chemist-meets-hip-hop dancer named the Dancing Scientist, running a one-man-show that automatically converts every stage into a classroom for zany science experiments.