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A photo of Stephanie Correa and Edward van Veen in Correa's UCLA laboratory

Research provides new insights into menopause and weight gain

A photo of Stephanie Correa and Edward van Veen in Correa's UCLA laboratory

Stephanie Correa and Edward van Veen in Correa’s UCLA laboratory (Photo Credit: Reed Hutchinson)

Can women in menopause get the benefits of hormone replacement therapy without the risks? A new UCLA study conducted with mice points in that direction, but additional research is necessary.

Women commonly experience hot flashes and weight gain, among other changes, during and after menopause. Hormone therapy, which gives women additional estrogen, can help alleviate some of these symptoms, but it has been linked to a higher risk of heart disease and breast cancer.

UCLA life scientists now report that a gene called reprimo, which is expressed by certain neurons in the brain, may play a role in menopause-related weight gain, a phenomenon not linked to increased eating. Their findings are published today in the journal Nature Metabolism.

“We want to figure out which neurons are mediating the beneficial portions of hormone therapy and mimic them without hormones,” said senior author Stephanie Correa, a UCLA assistant professor of integrative biology and physiology and a member of UCLA’s Brain Research Institute. “Hormone therapy can be beneficial, but it treats the entire brain and body with hormones. We may be able to bypass the hormone. That’s our goal, and it’s a big one. We haven’t achieved it yet, but we’re learning.”

Correa and her research team show that the reprimo gene is important for regulating temperature. Changes in temperature are known to affect body weight and may contribute to the weight gain often seen in menopause.

“It’s possible that reprimo is involved in the weight gain that accompanies menopause,” said co-lead author Edward van Veen, a project scientist in Correa’s laboratory. “If equivalent neurons exist in humans and we can find some way to tweak them, it might relieve much of the weight gain without the side effects of hormone therapy.”

A brain region called the hypothalamus is essential for survival in many species, from mice to humans; it controls eating, drinking, reproduction and body-temperature regulation, among other vital functions. Correa and her research team studied dozens of genes in the hypothalami of more than 50 mice, both female and male, starting at about eight weeks of age, shortly after they reach reproductive age.

The team used a technique known as single-cell RNA-seq, which allows biologists to study individual cells one at a time, to investigate which neurons in an area of the hypothalamus known as the ventromedial hypothalamus might mediate these different functions.

“We had hints there were different types of neurons in the ventromedial hypothalamus, and this region is very different in males and females, so we studied hundreds of cells in males and females to identify the different types of neurons and determine whether there are sex differences,” Correa said.

The biologists were most interested in neurons that have estrogen receptors. These receptors bind to the hormone and are subsequently able regulate to the activity of specific genes in the neuron, a process known as gene expression. The team’s most significant findings centered on the reprimo gene, which is expressed in one group, or population, of these estrogen-responsive neurons, restricted almost entirely to females.

“We were excited to find not only populations of estrogen-responsive neurons but also differences in these populations between males and females,” said co-lead author Laura Kammel, a former UCLA doctoral student in Correa’s laboratory.

“The difference between females and males in reprimo in the ventromedial hypothalamus is like night and day,” Correa said. “The females express a ton of it, and males express little, if any, reprimo in this brain region. Of the dozens of genes I have studied in this region, this is easily the strongest sex difference I have ever seen.”

In a series of experiments, the biologists interfered with the function of reprimo in the ventromedial hypothalamus in about two dozen mice. In one experiment, they shut off reprimo in female mice by using an RNA molecular compound that interferes with how the gene works in neurons. In another, they increased reprimo expression in male mice by removing an estrogen receptor from the neurons. In both cases, body temperature changed substantially, demonstrating a link between reprimo’s role in temperature and the effects of estrogen.

“We know that reprimo is important in regulating body temperature, but we don’t know what it is actually doing in neurons,” van Veen said. “We want to find out.”

Correa and her team also report that estrogen acts on another gene, Tac1, that is significantly increased in the ventromedial hypothalamus of female mice, although the difference is not nearly as dramatic as with reprimo. Tac1 has been shown to promote physical activity in female mice.

Estrogen receptor alpha, one of three estrogen receptors, is found in neurons in the same region of the ventromedial hypothalamus as Tac1 and reprimo. When the researchers removed that estrogen receptor, they found it led to obesity and reduced movement in female mice.

The results, the researchers said, not only aid in their understanding of the interplay between genes and estrogen but may also have implications for understanding obesity.

Summarizing the research, van Veen said: “The ventromedial hypothalamus is involved in movement and temperature regulation. We know estrogen affects movement and temperature. From Stephanie Correa’s previous research, we learned the estrogen response of neurons that affect movement, and now we think we know the estrogen response of neurons that affect temperature. It’s interesting that they are in the same location but distinct.”

“Our findings suggest reprimo is controlling some of the effects of estrogen on temperature,” Correa said. “If it is controlling the beneficial effects, then maybe we can manipulate it — with a drug that targets reprimo or the neurons that express reprimo — as an alternative to hormone therapy and get around the requirement for estrogen. We are studying the brain in a nuanced way and trying to learn which cells or which genes are important to target for potential therapies.”

Co-authors are co-lead author Laura Kammel, a former UCLA doctoral student in Correa’s laboratory; Xia Yang, a UCLA associate professor of integrative biology and physiology; Arthur Arnold, a UCLA distinguished professor of integrative biology and physiology; and Marc Liesa-Roig, a UCLA assistant professor-in-residence at the David Geffen School of Medicine at UCLA.

This article originally appeared in the UCLA Newsroom.

A photo of an article in the newspaper detailing the layoffs that continue to happen around the world.

With record unemployment filings, federal stimulus will help, but more is needed

A photo of an article in the newspaper detailing the layoffs that continue to happen around the world.

COVID-19 will plunge the United States economy into a recession. Photo Credit: by James Yarema on Unsplash

As an economist and director of the California Policy Lab, Till von Wachter is continually spearheading research projects and policy recommendations related to labor and employment as well as homelessness, education and crime.

As the U.S. economy further slows because of how the COVID-19 pandemic has forced so many businesses to close, UCLA Newsroom asked von Wachter, who is also the associate dean of research for the division of social sciences in the UCLA College, to help parse through current employment statistics, why the $2.2 trillion federal stimulus package called the CARES Act — which was signed into law March 27 — is so critical and what its immediate and far-reaching effects might be for U.S. workers and the economy.

How do you interpret the unemployment numbers that came out April 2?

The number of new claims to unemployment insurance — 6.6 million — was deeply alarming because that number is so much higher than what we’ve seen in previous recessions. Moreover, these numbers do not capture the many people out of work that are self-employed, have low wages, or for some other reason do not qualify for unemployment insurance. As CNBC noted, even in the worst week of the Great Recession, the number of claims were only 665,000 in March of 2009. The highest since the 1960s was 1,073,500 in the 1982 recession. Having studied unemployment, recessions and the policy responses to them for most of my academic career, I’m deeply concerned that if policymakers don’t act quickly, we could see a recession the likes of which our country has never experienced before. It will impact Americans for decades to come. There is still hope that the economy will turn back to normal after the Covid-19 pandemic is contained, but prolonged large-scale unemployment may be hard to reverse.

What will this mean for the U.S. economy and Americans who could be laid off in the coming weeks?

I have studied a range of situations where workers were hit by a sudden shock in the labor market, such as a job loss when a business suddenly lays off a large number of workers. The key here is to compare people who lost their jobs to a counterfactual of luckier workers who kept their jobs and that otherwise would have looked like them. The result from my research is that a worker with a steady job at a good employer that loses their job during a mass layoff in a recession will die 1.5 years sooner than they would have if they had not been laid off.  When you extrapolate that to an expected unemployment rate of 10% (approximately 10 million additional unemployed workers, which given the most recent week’s numbers may be a conservative scenario), my back-of-the-envelope calculations suggest a loss of 15 million life years. Beyond increased mortality, in separate research I have found these workers also suffer immediate and permanent earnings losses. Again, if those accrued to 10 million workers, it would amount to over $1 trillion dollars in earnings capacity lost over their lifetimes.

It’s also important to keep in mind more than 6 million individuals will graduate high school or obtain a college degree this year, and about 13 million workers age 16-24 are currently in the labor force. Hence about 20 million young individuals are of particularly high risk of exposure to a recession. Existing evidence suggests that unlucky labor market entrants suffer losses in earnings that last 10 to 15 years, depending on the severity of the recession. Yet, it appears their socioeconomic status declines again in middle age, and several studies have found that they experience higher rates of death over the long term. For example, entering the labor market during a large recession appears to reduce life-expectancy of young workers by about half a year. There would be an additional 10 million of life years lost from a prolonged recession.

Will the CARES Act help? 

The CARES Act is a good start. It includes significant funding spread out in a variety of ways to help sustain the economy while people practice safe distancing to defeat COVID-19. The additional pandemic unemployment assistance provided to the self-employed and others not covered by unemployment insurance benefits is of course an important aspect of the law. Yet, I argue in a recent proposal (PDF) that states need to act decisively and creatively to quickly scale up programs included in the CARES Act.

The funding Congress included for several programs that help firms to keep workers on their payroll could be a game-changer. This includes federal funding for “short-time compensation,” or STC, programs, sometimes also called work-sharing, as well as short-term emergency loans that include provisions for job stability.

In the same way that we are all “sheltering in place,” state employment departments — the agencies that administer unemployment benefits in every state — can use STC programs and equip companies to keep their employees in place. Under STCs, firms are able to reduce the hours of a large group of their employees (instead of laying just a few of them off), and employees can partially make up the difference in pay through receiving unemployment benefits. For a state like California that already has a functioning STC program, these STC benefits will be paid entirely by the federal government. This could lead to substantial saving for the state’s finances that will be likely very stretched in other ways.

Even better, the CARES Act also included a substantial subsidy for firms that were impacted by COVID-19 to help pay their workers’ wages. A small to mid-size firm that pays average wages could reduce the hours of their workers by 50% through shared-time compensation and have up to half of the remaining 50% of wages paid for by the federal government. This would be an instantaneous reduction of their wage bill by 75% while workers are kept on the job instead of flooding unemployment offices. Some businesses may find it hard to pay for even part of their workforce, perhaps because of large reductions in revenues or substantial fixed costs. The CARES Act also provides struggling businesses with the option to apply for short-term emergency loans through the Small Business Administration that would help them pay rent, wages and other operating costs. The key is that the repayment of these loans can be waived if the firm refrains from laying off their workers. Overall, firms now have a range of options to adjust to the economic conditions without laying off their workers.

How would states use short-time compensation?

Twenty-six states, including California, already have STC programs, meaning about 70% of the U.S. workforce could be covered. There is also funding in the law for the administrative costs of expanding these programs. For those 26 states, the federal government agreed to pay 100% of the benefits under STC programs.

Unfortunately, many employers are not currently aware of the program. Yet, states can be proactive in making the STC more attractive than layoffs to employers. Typically, if a firm lays off workers who receive unemployment insurance benefits, its payroll tax increases to help offset the costs to the unemployment insurance system. Yet, states could choose to pass on some of the cost-savings (from the federal government paying 100% of STC benefits) by committing not to raise the payroll tax for those firms that use STC instead of unemployment insurance. This incentive would help states to make a strong case for employers to use this program.

The key is to dispatch these funds quickly because failure to do so will likely lead to skyrocketing claims for unemployment insurance and serious bottlenecks in processing claims. It can also lead to substantial long-term effects on the income and health of people who are losing their jobs, young labor market entrants and others directly affected by the economic crisis. Unfortunately, many states’ STC programs are understaffed, such that there is a concern that bottlenecks may arise. In a recent proposal, I outline a proposal as to how states could quickly enroll thousands of firms despite these issues, such that these problems could also be surmounted.

The CARES Act also included $100 million in start-up grants for states that do not yet have STC programs, and if they do create them, the federal government will fund 50% of the benefits. While this is less than existing programs receive, it is still a great deal for workers, for firms, and for states because it means fewer layoffs, lower payroll taxes, and lower program expenditures, respectively.

This article originally appeared in the UCLA Newsroom.

A photo of James Lloyd-Smith.

Study reveals how long COVID-19 remains infectious on cardboard, metal and plastic

The virus that causes COVID-19 remains for several hours to days on surfaces and in aerosols, a new study published in the New England Journal of Medicine found.

The study suggests that people may acquire the coronavirus through the air and after touching contaminated objects. Scientists discovered the virus is detectable for up to three hours in aerosols, up to four hours on copper, up to 24 hours on cardboard and up to two to three days on plastic and stainless steel.

A photo of James Lloyd-Smith in his office.

James Lloyd-Smith

“This virus is quite transmissible through relatively casual contact, making this pathogen very hard to contain,” said James Lloyd-Smith, a co-author of the study and a UCLA professor of ecology and evolutionary biology. “If you’re touching items that someone else has recently handled, be aware they could be contaminated and wash your hands.”

The study attempted to mimic the virus being deposited onto everyday surfaces in a household or hospital setting by an infected person through coughing or touching objects, for example. The scientists then investigated how long the virus remained infectious on these surfaces.

The study’s authors are from UCLA, the National Institutes of Health’s National Institute of Allergy and Infectious Diseases, the Centers for Disease Control and Prevention, and Princeton University. They include Amandine Gamble, a UCLA postdoctoral researcher in Lloyd-Smith’s laboratory.

In February, Lloyd-Smith and colleagues reported in the journal eLife that screening travelers for COVID-19 is not very effective. People infected with the virus — officially named SARS-CoV-2 — may be spreading the virus without knowing they have it or before symptoms appear. Lloyd-Smith said the biology and epidemiology of the virus make infection extremely difficult to detect in its early stages because the majority of cases show no symptoms for five days or longer after exposure.

“Many people won’t have developed symptoms yet,” Lloyd-Smith said. “Based on our earlier analysis of flu pandemic data, many people may not choose to disclose if they do know.”

The new study supports guidance from public health professionals to slow the spread of COVID-19:

  • Avoid close contact with people who are sick.
  • Avoid touching your eyes, nose and mouth.
  • Stay home when you are sick.
  • Cover coughs or sneezes with a tissue, and dispose of the tissue in the trash.
  • Clean and disinfect frequently touched objects and surfaces using a household cleaning spray or wipe.

This article originally appeared in the UCLA Newsroom.

A photo of a 3D atomic structure information of a 2D material that was previously inaccessible due to the limitations of 2D images. A 2D image is shown beneath the 3D atomic coordinates of molybdenum in blue, sulfur in yellow and rhenium dopants in orange.

UCLA-led research team produces most accurate 3D images of ‘2D materials’

A photo of a 3D atomic structure information of a 2D material that was previously inaccessible due to the limitations of 2D images. A 2D image is shown beneath the 3D atomic coordinates of molybdenum in blue, sulfur in yellow and rhenium dopants in orange.

Image showing the 3D atomic coordinates of molybdenum (blue), sulfur (yellow) and added rhenium (orange). A 2D image is shown beneath the 3D model. (Photo Credit: Dennis Kim/UCLA)

A UCLA-led research team has produced in unprecedented detail experimental three-dimensional maps of the atoms in a so-called 2D material — matter that isn’t truly two-dimensional but is nearly flat because it’s arranged in extremely thin layers, no more than a few atoms thick.

Although 2D-materials–based technologies have not yet been widely used in commercial applications, the materials have been the subject of considerable research interest. In the future, they could be the basis for semiconductors in ever smaller electronics, quantum computer components, more-efficient batteries, or filters capable of extracting freshwater from saltwater.

The promise of 2D materials comes from certain properties that differ from how the same elements or compounds behave when they appear in greater quantities. Those unique characteristics are influenced by quantum effects — phenomena occurring at extremely small scales that are fundamentally different from the classical physics seen at larger scales. For instance, when carbon is arranged in an atomically thin layer to form 2D graphene, it is stronger than steel, conducts heat better than any other known material, and has almost zero electrical resistance.

But using 2D materials in real-world applications would require a greater understanding of their properties, and the ability to control those properties. The new study, which was published in Nature Materials, could be a step forward in that effort.

The researchers showed that their 3D maps of the material’s atomic structure are precise to the picometer scale — measured in one-trillionths of a meter. They used their measurements to quantify defects in the 2D material, which can affect their electronic properties, as well as to accurately assess those electronic properties.

“What’s unique about this research is that we determine the coordinates of individual atoms in three dimensions without using any pre-existing models,” said corresponding author Jianwei “John” Miao, a UCLA professor of physics and astronomy. “And our method can be used for all kinds of 2D materials.”

Miao is the deputy director of the STROBE National Science Foundation Science and Technology Center and a member of the California NanoSystems Institute at UCLA. His UCLA lab collaborated on the study with researchers from Harvard University, Oak Ridge National Laboratory and Rice University.

The researchers examined a single layer of molybdenum disulfide, a frequently studied 2D material. In bulk, this compound is used as a lubricant. As a 2D material, it has electronic properties that suggest it could be employed in next-generation semiconductor electronics. The samples being studied were “doped” with traces of rhenium, a metal that adds spare electrons when replacing molybdenum. That kind of doping is often used to produce components for computers and electronics because it helps facilitate the flow of electrons in semiconductor devices.

To analyze the 2D material, the researchers used a new technology they developed based on scanning transmission electron microscopy, which produces images by measuring scattered electrons beamed through thin samples. Miao’s team devised a technique called scanning atomic electron tomography, which produces 3D images by capturing a sample at multiple angles as it rotates.

The scientists had to avoid one major challenge to produce the images: 2D materials can be damaged by too much exposure to electrons. So for each sample, the researchers reconstructed images section by section and then stitched them together to form a single 3D image — allowing them to use fewer scans and thus a lower dose of electrons than if they had imaged the entire sample at once.

The two samples each measured 6 nanometers by 6 nanometers, and each of the smaller sections measured about 1 nanometer by 1 nanometer. (A nanometer is one-billionth of a meter.)

The resulting images enabled the researchers to inspect the samples’ 3D structure to a precision of 4 picometers in the case of molybdenum atoms — 26 times smaller than the diameter of a hydrogen atom. That level of precision enabled them to measure ripples, strain distorting the shape of the material, and variations in the size of chemical bonds, all changes caused by the added rhenium — marking the most accurate measurement ever of those characteristics in a 2D material.

“If we just assume that introducing the dopant is a simple substitution, we wouldn’t expect large strains,” said Xuezeng Tian, the paper’s co-first author and a UCLA postdoctoral scholar. “But what we have observed is more complicated than previous experiments have shown.”

The scientists found that the largest changes occurred in the smallest dimension of the 2D material, its three-atom-tall height. It took as little as a single rhenium atom to introduce such local distortion.

► Read a Nature analysis of the UCLA-led study

Armed with information about the material’s 3D coordinates, scientists at Harvard led by Professor Prineha Narang performed quantum mechanical calculations of the material’s electronic properties.

“These atomic-scale experiments have given us a new lens into how 2D materials behave and how they should be treated in calculations, and they could be a game changer for new quantum technologies,” Narang said.

Without access to the sort of measurements generated in the study, such quantum mechanical calculations conventionally have been based on a theoretical model system that is expected at a temperature of absolute zero.

The study indicated that the measured 3D coordinates led to more accurate calculations of the 2D material’s electronic properties.

“Our work could transform quantum mechanical calculations by using experimental 3D atomic coordinates as direct input,” said UCLA postdoctoral scholar Dennis Kim, a co-first author of the study. “This approach should enable material engineers to better predict and discover new physical, chemical and electronic properties of 2D materials at the single-atom level.”

Other authors were Yongsoo Yang, Yao Yang and Yakun Yuan of UCLA; Shize Yang and Juan-Carlos Idrobo of Oak Ridge National Laboratory; Christopher Ciccarino and Blake Duschatko of Harvard; and Yongji Gong and Pulickel Ajayan of Rice.

The research was supported by the U.S. Department of Energy, the U.S. Army Research Office, and STROBE National Science Foundation Science and Technology Center. The scanning transmission electron microscopy experiments were conducted at the Center for Nanophase Materials Sciences, a DOE user facility at Oak Ridge National Laboratory.

This article originally appeared in the UCLA Newsroom.

A photo of the Owens Valley lakebed.

Effort to limit dust pollution in Owens Valley is advancing, but still room to improve

A photo of the Owens Valley lakebed.

The Owens Valley lakebed with currently approved dust mitigation measures. (Photo Credit: David Colgan/UCLA)

The century-long battle over water between California’s Owens Valley and Los Angeles is nothing short of epic.

In 1974, the conflict was immortalized in the film “Chinatown.” The latest chapter comes in a more stoic but important form: a 157-page report from the National Academies of Sciences, Engineering and Medicine. The publication was created by a panel of experts that includes UCLA atmospheric dust specialist Gregory Okin.

Beginning in the late 1800s, William Mulholland quietly bought up land and water rights in Owens Valley, and in 1913, he started delivering the water from Owens Lake 233 miles south via aqueduct to a fast-growing Los Angeles.

The population of Los Angeles was 102,000 in 1910, but it had reached 319,000 in 1920 and then soared to 2 million by the middle of the century. Owens Valley, its lake drained of water, had become the largest source of dust in North America.

That dust included particulate matter measuring 10 micrometers or less in diameter, pollution that gets deep into people’s lungs and causes respiratory problems, particularly for sensitive groups. Ranchers, indigenous people and other residents of the valley were incensed, having lost their water and gained unhealthy air in its place.

The National Academies’ peer-reviewed report comes following decades of litigation that required the Los Angeles Department of Water and Power to take actions to mitigate the dust problem. Over the past two decades, the department has spent $2 billion on the effort.

And researchers found good news: Efforts between the department and Great Basin Unified Air Pollution Control District to control the issue have gone well. The work includes using gravel, managed vegetation and shallow flooding to mitigate dust. The air pollution district is a government agency responsible for protecting air quality in the east-central part of the state, near the Nevada border. It battled the Department of Water and Power in court for decades, but outside the courtroom the relationship is less contentious.

“The teams of people working on the ground together have been very successful,” said Okin, who is also a member of the UCLA Institute of the Environment and Sustainability. “There are still air quality exceedances that occur, but they are drastically smaller in magnitude and frequency than they were prior to 2000.”

That doesn’t mean there isn’t room for improvement. The report also recommended that processes for minimizing dust established 20 years ago should be updated with new technology and processes that would also help save water and power and preserve cultural and aesthetic values.

“Despite the fact that they’ve done a great job, they’ve done it in an ad hoc manner,” Okin said, referring to the two agencies. “There’s not a lot of logic as to what is being done and where.”

A photo of a crowd of 30,000 people who watched the first water cascade through the aqueduct in the San Fernando Valley.

A crowd of 30,000 watched the first water cascade through the aqueduct in the San Fernando Valley. (Photo Credit: Courtesy of waterandpower.org)

The methods workers can use to mitigate dust are strictly controlled by a series of legal agreements. And testing new methods poses a challenge, because testing is prohibited in the areas of the valley in which dust pollution has been substantially controlled.

“The only place you can test new measures is in areas that don’t need to be controlled, which is crazy,” Okin said.

The report suggests that the air pollution control district and the Department of Water and Power work together to redesign the entire system of dust control in the lakebed.

“The current work is probably using more water, power and heavy machinery than it needs to,” Okin said.

Better managing the area could also be a boon for wildlife. Currently, one of the main approaches to mitigating dust in the area is to plant grass, which requires a lot of irrigation. Okin suggested other native species could replace grass in some areas, which would save water and create new living spaces for birds, rare aquatic life and other species wildlife.

The report also notes that planning for future efforts must account for also climate change, which is projected to increase temperatures and make precipitation patterns and dry spells more extreme. The 2017 rainy season, for example, flooded the valley with more water than the Los Angeles Aqueduct could take, causing water levels in the mostly-dry lake to rise substantially.

The competing interests of the two main players could make it difficult to improve the situation further, Okin said. While the air pollution control district is primarily interested in dust mitigation, the Department of Water and Power cares mostly about conserving water as a resource. Bringing new efficiency and sustainability to the process would likely require further involvement of third parties such as the academies that created the report.

It’s been more than a century since Mulholland said, “There it is, take it,” as the first Owens Valley water flowed through the aqueduct into Los Angeles. Now, the question is how the next century of this drama, which affects the lives of millions, will unfold.

This article originally appeared in the UCLA Newsroom.

A photo of an I voted sticker.

USA Today harnesses UCLA political scientists’ ‘Nationscape’ data

A photo of an I voted sticker.

I voted sticker. Jessica Whittle Photography/Creative Commons 2.0. (Photo Credit: Jessica Whittle Photography)

As voters in 14 states, including California, go to the polls March 3 to vote for their preferred Democratic presidential nominee, information gathered by UCLA professors Lynn Vavreck and Chris Tausanovitch will offer data-based insights about what voters care about most.

Every week, observations and analysis from their massive Nationscape voter data project will be published on USA Today. The newspaper’s first published report on this project, which is a partnership between UCLA, Washington, D.C.-based Democracy Fund and the market research firm Lucid, launched Feb 28.

“At a moment when everyone from voters to pundits is focused on who is ahead and who is most electable in November, our data about what people care about and how this varies across geography and demographic groups in the United States can hopefully inject a dose of substance in to conversations about electioneering and strategy,” Vavreck said. “We are delighted that USA TODAY wants to visualize our data for their readers in the lead up to the 2020 presidential election. With their reach, they are able to share insights from our Nationscape project with people in real time.”

Vavreck and Tausanovich have been deep in the throes of Nationscape data gathering since summer 2019, conducting about 6,250 interviews each week. By election time, they will have done 500,000 interviews asking people about policy questions and their opinions about the attributes of elected officials. The way the data is presented allows respondents to really think about what they care about most, and also consider what they are willing to give up to get it. Researchers are also tracking how those attitudes might change over time.

The USA Today story that posted Feb. 28 reveals a wealth of information on voter attitudes about gun control, immigration, middle class tax cuts, health care and more.

There are issues where attitudes overlap between Democrats and Republicans — background checks for gun ownership and middle class tax cuts — while topics like building a border wall shows a starker split based on party affiliation.

A tax cut for families who make less than $100,000 is a particularly fertile ground for commonality. According to Nationscape, 79% of Democrats agree with cutting taxes for families that make less than $100,000 per year, while 10% disagree. Among Republicans, 70% agreed, while 18% disagreed.

When it comes to Americans who are most likely to vote Democrat, the policy with the widest variance of support is Medicare for All, according to Nationscape data released last week.

For supporters of all the Democratic candidates still in play for Super Tuesday, a majority of these likely voters agree with the idea of Medicare for All, regardless of their chosen candidate. Sentiments run strongest among supporters of Bernie Sanders for whom it is a signature campaign issue, with 87% of his voters agreeing with Medicare for All. For Elizabeth Warren, 67% of her supporters agree with the policy. When it comes to Joe Biden and Mike Bloomberg, 58% and 57% of their supporters, respectively, agree with Medicare for All.

An employment among homeless graphic.

Nearly 75% of L.A. County’s homeless previously worked in California

An employment among homeless graphic.

Illustration of a retail employee superimposed over a Los Angeles street map. (Photo Credit: California Policy Lab)

report published Feb. 26 by the California Policy Lab at UCLA sheds light on people’s employment histories before, during and after they received homelessness services in Los Angeles County.

The report’s authors studied data for more than 130,000 people who received homeless services from Los Angeles County. They found that 74% of people who experienced homelessness had some work history in California and that 47% had worked in the four years prior to becoming homeless.

But only 19% had worked in the calendar quarter they became homeless, and the average annual earnings for people who worked before experiencing homelessness was only $9,970 in the year before they became homeless — just 16% of the Los Angeles area median income of $61,015.

“There’s often an assumption that people experiencing homelessness are not working,” said Till von Wachter, a co-author of the report and faculty director of the California Policy Lab at UCLA. “While it’s true that some individuals in our study had not worked in a long time, a substantial number — close to half — were working within four years before entering homelessness. These recent workers had a higher likelihood of returning to work after receiving services and their average earnings were also higher.”

Von Wachter, a UCLA economics professor, said the study’s findings — particularly those on who is most likely to work after enrolling for homeless services — could be used to tailor workforce programs that would help people who are receiving services to find employment and to increase the earnings of homeless service clients.

The study’s three main findings:

The likelihood of people finding employment after they enrolled in homeless services varied widely based on demographic factors and work history. For example, people who were recently employed before becoming homeless and younger people were more likely to be employed after homelessness. To a lesser degree, adults in families, and people without mental and physical health issues also had higher employment rates than the average for the entire sample. Understanding those differences could help officials better target services to those who are most likely to find gainful employment.

The employment rates for certain groups of people in the study improved within the two-year period after they enrolled to receive homeless services, although the authors pointed out that the relationship between the two facts may not be causal. For example, people in transitional housing and people who came from stable housing saw increases in employment rates after enrolling.

Sixty-five percent of the people in the study worked in four broad job categories prior to enrolling in homeless services: 28% in administrative support, waste management and remediation services; 14% in health care and social assistance fields; 12% in accommodation and food services; and 11% in retail. That finding could help inform the types of job training and placement programs that could help prevent homelessness or help people transition out of homelessness.

For the study, the researchers used data from the Los Angeles Homeless Services Authority from 2010 to 2018 for people who were 18 to 70 years old at the time they enrolled for services, and state employment records from the California Employment Development Department for 1995 to 2018.

The authors wrote that although report should improve understanding of employment trends among people who receive homeless services in Los Angeles, more research is needed to develop specific policy recommendations. Future research should examine whether job loss is the direct cause of homelessness and for whom, and how workforce and training programs could either prevent homelessness or accelerate exits from homelessness.

The California Policy Lab creates data-driven insights for the public good. Based at UCLA and UC Berkeley, it partners with researchers at other University of California campuses, as well as with California’s state and local governments to generate scientific evidence that solves California’s most urgent problems, including homelessness, poverty, crime and education inequality.

This article originally appeared in the UCLA Newsroom.

 

Ellen DuBois, professor emerita of history in the UCLA College and author of “Suffrage: Women’s Long Battle for the Vote.”

Historian’s new book traces three generations of suffragists

Ellen DuBois, professor emerita of history in the UCLA College and author of “Suffrage: Women’s Long Battle for the Vote.”

Ellen DuBois observes that expanding the vote is still not something established political leaders are eager to do. (Photo Credit: Scarlett Freund)

They persisted.

August 2020 marks the 100th anniversary of the ratification of the 19th Amendment, which ensured that all American women could vote in federal elections. Ellen DuBois, UCLA professor emerita of history, has devoted her academic life to the stories of the women (and men) whose unrelenting, passionate and organized advocacy withstood 75 years of shifting partisan politics to finally enfranchise women in the U.S.

Written for anyone who cares about rights in America, her latest book, “Suffrage: Women’s Long Battle for the Vote,” which came out Feb. 25, takes a comprehensive look at the incomparable effort.

Her storytelling illuminates the lives and efforts of three generations of suffragists, as her prose passes the baton from woman to woman, grandmother to mother, mother to child. She celebrates the efforts of such champions as Carrie Chapman Catt and Alice Paul, who were critical in the final push into the 20th century, and she illustrates how African American women — led by Ida B. Wells-Barnett, Mary Church Terrell and Mary Ann Shadd Cary — demanded voting rights, even when white suffragists ignored them.

In a presidential election year, and as primary voters head to the polls for Super Tuesday on March 3, it is fitting to heed activist Gloria Steinem’s praise for DuBois’ work:

“Ellen DuBois tells us the long drama of women’s fight for the vote, without privileging polite lobbying over radical disobedience — or vice versa. In so doing, she gives us a full range of tactics now, and also the understanding that failing to vote is a betrayal of our foremothers and ourselves.”

We asked DuBois to share some of the key takeaways from “Suffrage.”

The Americans who took up the fight for women’s right to vote were originally proponents of “universal suffrage,” which would have meant a constitutional amendment affirming votes for every American citizen over the age of 18 — regardless of race or gender. How different might this battle have been if that original purpose had been successful?

The Constitution gives little control to the federal government over voting — just times, places, etc. — and none whatsoever over who gets to vote. The three voting amendments, including the 19th, barely tamper with that, only forbidding the states from named disenfranchisement. And as we know from the history of African American voter suppression, those are easy to get around.

If the suffragists’ early attempt to reframe voting as a positive right of national citizenship [had been successful], much of what we suffer today by way of voter suppression — which comes from the states — would no longer be legal or constitutional. We would have universal enfranchisement, which we cannot say we have now.

A photo of the cover of “Suffrage: Women’s Long Battle for the Vote.”

“Suffrage: Women’s Long Battle for the Vote” Photo Credit: Simon & Schuster

This book is also a fascinating rendering of the kaleidoscopic nature of American partisan politics. What was the biggest obstacle to women’s suffrage?

This is a question that suffragists and historians have long pondered. General male opposition to women taking a place in politics, as well as women’s hesitation about leaving their traditional roles, certainly played a part.

But as I studied the last few decades of the movement, I was especially struck by the determination of politicians to keep women without votes — both at the national level, fighting against amendment passage, and the state level, opposing ratification, the ultimate obstacle.

This was the case even when it was clear to the final opponents that women’s suffrage was inevitable. Politicians’ opposition certainly reflected their own conservative ideas about who women were — their delicate wives and the pesky radicals who wanted the vote — but it was also a political calculation. The suffragists and other social activist women had developed a solid reputation as nonpartisan reformers, and politicians didn’t want that. Finally, it was impossible to predict which party enfranchised women would favor. It turned out to be both.

As we know from our own times, expanding the vote is still not something established political leaders are eager to do.

By the time the 19th Amendment was passed, millions of women already had the right to vote in federal elections, thanks to state constitutions. By 1919, women in Wyoming and Colorado had voted in five or six presidential elections. Western states like California were critical to eventual nationwide suffrage. Who were some of the most important suffragists who helped win the vote in California?

California, when it amended its state constitution to enfranchise women in 1911, was the sixth state to do so — and by far the most important.

Maud Younger was a wealthy San Franciscan, among those young people known as “new women” for their eagerness for modern lives and new experiences. She left home, went to New York City, worked as a waitress and trade union activist, and returned to California to organize working women. They called her the “millionaire waitress.” She was responsible for getting the brewers union on board, which helped to overcome suffragists’ reputation for being anti-alcohol.

Sarah Massey Overton, an African American woman from San Jose, not only organized her area’s African American community, but — unusual for these years — worked closely with white suffragists in the interracial Political Equality League.

Hispanic Californian suffragists were harder to trace. I located a very interesting woman, Maria de Lopez, whose family was in California before its statehood. As of 1910, she was a college graduate and taught at UCLA and later was a scholar of Spanish-language literature. Fascinating!

Multiple other amendments to the U.S. Constitution were ratified before the 19th. How did the push for these amendments affect the fight for women’s suffrage? Why was the 17th Amendment critical to the eventual passage and ratification of the 19th?

The reconstruction amendments 14th and 15th were crucial: the latter for omitting women from the expansion of the franchise, which angered suffragists; the former for establishing — for the first time — national citizenship, which led hundreds of suffragists to claim the right to vote in the 1870s including Susan B. Anthony.

It was several decades before other amendments were added. The 17th made the election of senators dependent on the people’s vote, when previously they were appointed by state legislators. This played a role in breaking the final opposition to the women’s suffrage amendment in the upper house. The 18th Amendment [prohibition of alcohol] took this contentious issue, often associated with women voters, off the table and removed an issue of the opposition.

Do you have a favorite suffragist? If so, who and why?

I’m often asked this. I do love Elizabeth Cady Stanton for her brilliant insights into the multifaceted nature of women’s subordination and her vision for broad freedoms for women. These days she is remembered more for her racist and elitist outbursts against men who voted before women, but I think she has more to offer us than just that. These women are all so great, so varied, so brave, so determined — “nevertheless they persisted.” I love them all.

Your book also illustrates the power of an archive. Susan B. Anthony had the brilliant foresight to establish a multivolume history of the movement — including photographs and images of suffragists — and then donated copies to libraries and universities for posterity. Obviously this was critically important to historians like yourself and Eleanor Flexner, who wrote 1959’s “Century of Struggle.” What other stories are waiting to be told from this archive? What are you working on next?

The suffrage movement is unique for its geographical breadth and depth. It lasted so long, and constitutional amendments, which are contested like this one, require organized activism in virtually every state. There is so much more to be said about suffragists in our country.

A second issue is a more complex one: the varied and painful history of racism within the suffrage movement, which lasted from the years of emancipation through the height of the Jim Crow era.

Finally, and this is one of my unfinished projects, women’s enfranchisement was an international issue. In almost every country where women have received the right to vote, they have organized to fight for it. It was rarely given. I’m working on that in the interwar years.

My next big project is a major biography of Elizabeth Cady Stanton, who has never really had one. I’m going to give her that.

DuBois is on a speaking tour for the book, including several upcoming events in town.

March 7 at 2 p.m. — “The Surprising Road to Woman Suffrage” illustrated book lecture at Los Angeles Public Library’s Central Library

March 8 at 1 p.m. — “The Right to Vote Then and Now” panel discussion at Royce Hall. Also featuring Adam Winkler, Brenda Stevenson, Katherine Marino, Sheila Kuehl and Sandy Banks.

March 14 at 11 a.m. — “The Surprising Road to Woman Suffrage” Caughey Foundation Lecture at the Autry Museum of the American West

March 15 at 2 p.m. — Book presentation with Jessica Millward, UC Irvine associate professor of history, and Culver City Mayor Meghan Sahli-Wells at the Wende Museum

This article originally appeared in the UCLA Newsroom.

A photo of Professor Tracy Johnson.

Professor Seeks to Provide All Students with a Pathway to Research Success

A photo of Professor Tracy Johnson.

Professor Tracy Johnson, Keith and Cecilia Terasaki Presidential Endowed Chair in the Life Sciences, with undergraduate students in her research lab. (Photo credit: UCLA Strategic Communications.)

When Tracy Johnson was an undergraduate working in a lab at the University of California at San Diego, she found herself suddenly jolted. Conducting research on gene function using fruit flies, she realized she was involved in something deeper and more fulfilling than a traditional classroom experience. “The idea that I was learning things that nobody else knew, that I could make some contribution,” she says now, “that was a game-changer.”

Professor Johnson arrived at UCLA College’s Department of Molecular, Cell and Developmental Biology in 2014, aiming to bring this same sense of purpose to others. She founded the UCLA-HHMI Pathways to Success, a program that seeks to give students from diverse backgrounds an “authentic research experience, early on, and in a prolonged way.” For years, she says, students of color and those who were the first in their family to attend college pursued STEM degrees at equal rates as other students but left STEM majors at a higher rate.” “I think that has less to do with preparation,” she says, “and more to do with not seeing themselves as part of a scientific community. Pathways was designed to rethink that.” The goal was to help students understand they belonged and had important contributions to make.

In building the program, Johnson looked around the country to find what worked best, and bring it to UCLA. She was interested not just in lab work but in mentoring as well.

Pathways students participate in a lab course dedicated to Johnson’s field, gene expression. The DNA in every cell of a given plant or animal are identical. Expression is the process by which specific segments of the DNA, genes, get turned on.  This process allows cells to perform specific functions. For example this process can tell a cell to become part of a muscle, part of the bran, and so on.

It’s a lot to throw first-year students into, she acknowledges. “They’re freshmen, on campus for barely 10 weeks if it’s winter quarter. Some have never taken AP biology. It’s ambitious, but they rise to the occasion.”

In fact, she’s expecting to publish some of the student research in an academic journal in 2020. Pathways has now enrolled close to 100 students, and they’ve taken on more and more responsibility as the years have passed. Some have gone on to doctoral programs, others to medical school. “There isn’t anything quite like what we do,” she says. “I think it’s a model for how to think about student success.”

Find out more about UCLA College’s innovative Pathways program.

An illustration that shows the Earth’s magnetosphere during a magnetic storm.

Researchers discover a new source of space weather – too close to home

An illustration that shows the Earth’s magnetosphere during a magnetic storm.

An illustration shows the Earth’s magnetosphere during a magnetic storm. At right, three satellites witnessed reconnection close to geosynchronous orbit where many other critical satellites reside. The red “X” identifies the reconnection site, and the yellow arrows indicate the direction of explosive outflows of energized particles toward and away from Earth. Earth-directed electrons (shown in red and pink) carry energy along magnetic field lines to power the aurora at Earth’s north and south poles. These energized electrons were detected by a weather satellite (center).

Beyond Earth’s atmosphere are swirling clouds of energized particles — ions and electrons — that emanate from the sun. This “solar wind” buffets the magnetosphere, the magnetic force field that surrounds Earth.

In much the same way winds and storms create weather in our atmosphere, strong gusts of solar wind penetrating the magnetosphere can generate magnetic storms with powerful electric currents that can impact our lives.

A new study by the NASA THEMIS mission team — led by Vassilis Angelopoulos, a UCLA professor of space physics — is the first to show that such storms can originate much closer to Earth than previously thought, overlapping with the orbits of critical weather, communications and GPS satellites. The team’s findings are published in the journal Nature Physics.

Magnetic storms can produce dazzling northern lights or hazardous particles careening toward spacecraft and astronauts, zapping them out of commission. Under certain conditions, magnetic storms can disable the electrical grid, disrupt radio communications and corrode pipelines, even creating extreme aurora visible close to the equator.

“By studying the magnetosphere, we improve our chances of dealing with the greatest hazard to humanity venturing into space: storms powered by the sun,” Angelopoulos said.

An incident that illustrates the dramatic power of magnetic storms occurred in 1921, when such a storm disrupted telegraph communications and caused power outages that resulted in a New York City train station burning to the ground. And in 1972 the Apollo 16 and 17 astronauts narrowly missed what could have been a lethal solar eruption. These incidents underscore the potential dangers that should be assessed as more humans venture into orbit. If a similar storm occurred today, a separate study estimated, economic losses in the U.S. due to electrical blackouts only could surpass $40 billion a day.

How electric currents in space influence the aurora and magnetic storms has been long debated in the space physics community. Because the storms occur so rarely and satellite coverage is sparse, it has been difficult for researchers to detect the dynamic process that powers those storms.

When solar wind magnetic energy is transferred into the magnetosphere, it builds up until it is converted into heat and particle acceleration through a process called magnetic reconnection. After decades of study, it is still unclear to researchers where exactly magnetic reconnection occurs during storms.

Recent observations by multiple satellites have shown that magnetic storms can be initiated by magnetic reconnection much closer to Earth than previously thought possible. The three NASA THEMIS satellites observed magnetic reconnection only about three to four Earth diameters away. The researchers did not expect this could happen in the comparatively stable magnetic field configuration near Earth.

Later, a weather satellite, which was nearer to Earth in geostationary orbit, detected energized particles associated with magnetic storms.

The weather satellite proved that this near-Earth reconnection stimulated ion and electron acceleration to high energies, posing a hazard to hundreds of satellites operating in this common orbit. Such particles can damage electronics and human DNA, increasing the risk of radiation poisoning and cancer for astronauts. Some particles can even enter the atmosphere and affect airline passengers.

“Only with such direct measurements of magnetic reconnection and its resulting energy flows could we convincingly prove such an unexpected mechanism of storm power generation,” said Angelopoulos, who is lead author of the paper. “Capturing this rare event, nearer to Earth than ever detected before, forces us to revise prior assumptions about the reconnection process.”

This discovery will ultimately help scientists refine predictive models of how the magnetosphere responds to solar wind, providing precious extra hours or even days to prepare satellites, astronauts and the energy grid for the next “big one” in space.

This article originally appeared in the UCLA Newsroom.