A photo of Michelle Craske.

Michelle Craske to share how research can inform anxiety and depression treatment

A photo of Michelle Craske.

Michelle Craske and colleagues are studying how to integrate virtual reality into treatment for anxiety and depression. Photo Credit: Reed Hutchinson/UCLA

For more than three decades, Michelle Craske has been trying to understand what makes some people prone to anxiety and depression. She’s studied what biomarkers, behaviors and thinking patterns contribute to these conditions, and how to use that knowledge to develop better treatments.

At the 128th Faculty Research Lecture, Craske, distinguished professor of psychology in the UCLA College, will describe some of her findings and talk about how virtual reality has begun playing a role in changing patients’ mindsets for the better. The talk will be held at 3 p.m. on Wednesdsay, Feb. 19.

“Anxiety and depression are dramatically increasing in prevalence,” said Craske, who is also a professor of psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA and holder of the Joanne and George Miller and Family Endowed Chair. “We need to understand the engine that’s driving these conditions so we can improve our treatments.”

In the U.S., only about half of people with symptoms of anxiety or depression receive treatment. And when they do get help, treatments are only effective about half the time, said Craske, also an executive committee member for the UCLA Depression Grand Challenge, a campus-wide initiative that aims to cut the global burden of depression in half by 2050.

Much of Craske’s work on anxiety centers on the idea that people prone to anxiety disorders, which affect an estimated 18% of U.S. adults each year, anticipate threat more often than others and have difficulty inhibiting this fear. Most people feel fearful when faced with a real threat — say, a bear in front of us in the woods. But people most at risk for anxiety disorders are more likely to respond to an uncertain situation — feeling afraid in the woods even when there’s no bear, for instance.

The challenge for clinicians like Craske is to decrease this anticipation of threat. Craske uses a technique known as exposure therapy, in which a person is exposed to a situation or setting that makes them anxious, in an attempt to train their brain that it’s safe. Craske utilizes prediction error learning to explain the effects of exposure therapy and attempts to optimize such learning. The greater the element of surprise, the more the learning sticks.

“We want to design a treatment where a person says, ‘Oh, I was wrong! I really expected this to be unmanageable or even risky and it wasn’t at all,’” Craske said.

Craske’s research aims to make people with depression — or those prone to depression — more motivated to work toward and to savor rewards. This “reward sensitivity” is often dampened by depression and Craske thinks it’s an avenue for potential treatments to target. For example, in her studies of the effects of kindness and compassion on depression, she has found that training people how to more regularly engage in acts of kindness can ease their symptoms.

Craske and colleagues also are studying how to integrate virtual reality into treatment for anxiety and depression.

“We use virtual reality to help people face the situations they fear and avoid, and at other times we use virtual reality to increase their capacity for positive emotions,” she said. “By immersing themselves in positive scenes we can teach them how to anticipate and savor rewarding events and then transfer that to real life.”

In her talk, titled “Anxiety and Depression: Risk Factors and Treatment,” Craske wants to convey a sense of her scientific approach, which builds off her background as a clinical psychologist to improve psychotherapies. It will take many different perspectives, however, to solve anxiety and depression, she said. In her role with the Depression Grand Challenge, she helps build collaborations between researchers like herself and those that study psychological diseases from a genetic, molecular or neurological point of view.

Craske looks forward to presenting her research, and hopes the audience comes away from her lecture feeling hopeful about the progress that science is making on anxiety and depression.

“I am deeply honored to have been selected to give this lecture which represents the true pinnacle of my career at UCLA,” Craske said.

The Faculty Research Lecture — a UCLA tradition since 1925 — is free and open to the public and will be held at 3 p.m. on Feb. 19 in the Schoenberg Music Building. Please RSVP here if you’d like to attend.

This article originally appeared in the UCLA Newsroom.

A photo of images of fruit flies’ eyes, wings and lymph glands.

Hundreds of UCLA students publish paper analyzing 1,000 genes involved in organ development

A team of 245 UCLA undergraduates and 31 high school students has published an encyclopedia of more than 1,000 genes, including 421 genes whose functions were previously unknown. The research was conducted in fruit flies, and the genes the researchers describe in the analysis may be associated with the development of the brain, eye, lymph gland and wings.

The fruit fly is often the object of scientific research because its cells have similar DNA to that of human cells — so knowledge about its genes can help researchers better understand human diseases. The UCLA study should be useful to scientists studying genes involved in sleep, vision, memory and many other processes in humans.

The research is published in the journal G3: Genes, Genomes, Genetics. The study’s senior authors include researchers Cory Evans and John Olson, who taught UCLA’s Biomedical Research 10H, the course in which the studies were conducted.

“I expect this will be a highly cited paper and a valuable resource to life scientists,” said Tracy Johnson, director of UCLA’s biomedical research minor, which offers the course the students all took. “It’s inspiring to know all of this really important research came from freshmen and sophomores. It’s beautiful, high-quality research.”

A photo of images of fruit flies’ eyes, wings and lymph glands.

Visible on this page are images of fruit flies’ eyes (top), wings and lymph glands, showing which genes are active (red) or were previously active (green). (Download the full image to also see scans of the brain.) Photo credit: Cory Evans

The students studied short DNA sequences to learn how specific genes are turned on and off and understand how those genes control the functions of various cell types. Although all cells have essentially the same collection of genes, specific genes are turned on or off depending on the cells’ needs, Evans said.

Each student studied several genes, ultimately producing a total of more than 50,000 microscopic images; the researchers then posted their analysis on an online database where other scientists can study the genes’ roles.

“This shows not only which genes are turned on, but the history of which genes have been turned on,” Johnson said.

The research was conducted as part of a UCLA life sciences course that was developed in the early 2000s by Utpal Banerjee, a UCLA distinguished professor of molecular, cell and developmental biology, a Howard Hughes Medical Institute Professor and a senior author of the paper. The course received initial funding from the HHMI.

“Research on science education says that one of the best way to teach science is by having authentic research experiences embedded in a course,” said Johnson, who holds the Keith and Cecilia Terasaki Presidential Endowed Chair in the Division of Life Sciences and is an HHMI Professor. “Professor Banerjee understood years ago when he envisioned the class that students learn more by doing science. They learn how to design experiments, how to think like scientists, how to write about science and how to present their research.”

Johnson said the approach is analogous to teaching a sport. “If a kid wants to play soccer, you don’t say, ‘Don’t touch the soccer ball yet. You have to first learn all of the rules, watch other people play and read about the soccer greats, and maybe in a couple of years, we’ll let you kick the ball.’ No, bring out the soccer balls! So we need to get science students in the lab.”

The students completed two other research projects, one of which Evans expects will be published this year. In that study, the undergraduates studied the effects of turning off specific genes in fruit flies using a scientific technique called RNA interference. They then determined which of those 4,000 genes, when turned off, affect the proper development of blood cells.

“We teach students how to do research, not fly biology,” said Evans, who is now an assistant professor of biology at Loyola Marymount University. “Their science literacy is high, and they know how to evaluate evidence.”

This article originally appeared in the UCLA Newsroom.

Photo of group of volunteers at first mobile health clinic.

Student launches mobile health clinic to increase access to care

Photo of group of volunteers at first mobile health clinic.

Ahmad Elhaija, center, with International Collegiate Health Initiative medical staff, volunteers and student team members at the organization’s first mobile health clinic. Photo: Reed Hutchinson/UCLA

On a sunny autumn Saturday at the Southeast-Rio Vista YMCA in the city of Maywood, kids colored drawings and played Jenga while their parents and other family members underwent basic health screenings conducted by volunteer nurses.

After their bloodwork and other tests were done, the people met with doctors from medical centers in southeast Los Angeles County to discuss their results. Aided by Spanish-language translators, the doctors also gave advice about everything from medications to old injuries — anything the patients wanted to know.

The free event, attended by about 40 community members plus their children, was the first mobile community health clinic hosted by the International Collegiate Health Initiative. Founded two years ago by UCLA junior psychobiology major Ahmad Elhaija, the initiative aims to increase access to affordable, high-quality medical care in low-income and refugee communities in Los Angeles through mobile community health clinics and social advocacy.

“I thought, what can we do here that’ll make a big impact, where we can affect the statistics of a community, their health outcomes?” he said.

Elhaija drew inspiration for the project from two aspects of his youth in Anaheim — growing up frequently sick without consistent health insurance and his volunteer work assisting Arab and Muslim refugees.

Given the need for this kind of service, Elhaija applied for the annual Donald A. Strauss Foundation scholarship to help implement his vision. Each year, the Strauss Foundation awards 10 to 15 students from across 14 California colleges a $15,000 scholarship which is divided between the student’s educational costs and a grant for the public service project they propose in their application.

Elhaija was the only UCLA student to win the $15,000 scholarship in 2019. In 2018, two UCLA students won the Strauss scholarship; their projects helped transfer students prepare for doctoral programs, and provided therapy and support for K-12 students who stutter.

Photo of Ahmad Elhaija

Ahmad Elhaija Photo: Reed Hutchinson/UCLA

As part of the scholarship, Elhaija was assigned a mentor to advise him on his project. Elhaija’s mentor, Marc Anthony Branch, is a program officer for sustainable development for the United Methodist Committee on Relief and an expert in grant writing. Elhaija relied on Branch’s knowledge to improve his grant writing skills.

“I set him up with my grant-writing team, and he was really pivotal in actually getting us moving forward,” Elhaija said. “Before him, we didn’t really have much progress in grant writing, so having him on board and him giving his expertise was really cool. He knows what grant-giving organizations are looking for and he has some good contacts in that realm as well.”

Growing up in a low-income neighborhood in Anaheim, Elhaija was frequently sick from asthma and a rare blood disorder called cyclic neutropenia. His family didn’t always have health insurance, and although they worked hard to support and care for him, they were often left with high hospital bills.

While his family’s difficulty navigating his health care opened his eyes to the importance of providing affordable care, as a teenager Elhaija also volunteered at the nonprofit Access California Services, which provides support and resources to Arab and Muslim refugees in Anaheim. He said that volunteering with the organization and seeing the services for refugees that were still lacking inspired him to think of ways he could help.

So when Elhaija got to UCLA in 2017, he formed the International Collegiate Health Initiative with the goal to provide medical care to refugees in countries like Syria and Palestine. Through his volunteer work and visiting his own family in the Middle East, Elhaija learned that college campuses would be the safest places to provide medical services in the region.

However, finances and logistics made it more productive for Elhaija to focus his efforts on refugee and low-income communities closer to home. So he switched the initiative’s focus to offering mobile community health clinics in southeast Los Angeles.

The initiative is managed by a team of 20 students, a board of directors and professional advisers who offer guidance and medical services for the clinics. The clinic in Maywood, held on Nov. 16, was the organization’s first mobile health clinic. Another is planned for the city of Bell in February.

The ICHI’s ultimate goal is to raise enough money for a mobile clinic van, and to expand to other cities in California or even overseas.

“The idea is that we could have our full blown mobile clinic running in the fall of next year, where we can provide basically every type of care that a standard clinic can provide,” Elhaija said.

This article originally appeared in the UCLA Newsroom.

Chronic opioid treatment may raise risk of post-traumatic stress disorder, study finds

Senior author Michael Fanselow said the research suggests that chronic opioid use increases susceptibility to developing anxiety disorders. Photo credit: Reed Hutchinson/UCLA

While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD.

In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks. After the morphine wore off, the mice were given mild electric foot shocks. These mice showed a substantially longer “freezing response” than a second, control group of 24 mice that had not been given morphine. When mice recall a frightening memory, they freeze. Their heart rates and blood pressure go up, and the more frightening the memory, the more they freeze.

“While we are generally aware that drug use, such as that in the current opioid crisis, has many deleterious effects, our results suggest yet another effect — increased susceptibility to developing anxiety disorders,” said senior author Michael Fanselow, UCLA distinguished Staglin family professor of psychology and director of UCLA’s Staglin Family Music Festival Center for Brain and Behavioral Health. “As opioids are often prescribed to treat symptoms such as pain that may accompany trauma, caution may be needed because this may lead to a greater risk of developing PTSD, if exposed to further traumatic events, such as an accident, later on.”

“The foot shocks produced lasting fear and anxiety-like behaviors, such as freezing,” Fanselow said.

“Our data are the first to show a possible effect of opioids on future fear learning, suggesting that a person with a history of opioid use may become more susceptible to the negative effects of stress,” Fanselow said. “The ability of opioids to increase PTSD-like symptoms far outlasted the direct effects of the drug or withdrawal from the drug, suggesting the effect may continue even after opioid treatment has stopped.”

Fanselow’s view is if there is reason to believe a patient is likely to experience severe emotional stress after opioid treatment, then doctors should use caution about prescribing an opioid. If opioid use is medically called for, then the patient should be kept away from potentially stressful situations. So, for example, a soldier treated with opioids for pain should not be sent back into combat for a period of time, he said. The development of post-traumatic stress disorder requires some stressful experience after opioid use, he said.

The researchers also gave some of the mice morphine after the initial trauma had occurred but before exposing them to the second, mild stressor. They found that mice treated with morphine after the initial trauma did not show enhanced fear learning following exposure to the mild stressor. This finding suggests that chronic use of opioids before — but not after — a traumatic event occurs affects fear learning during subsequent stressful events.

The researchers concluded the mice given morphine were more susceptible to post-traumatic stress disorder than the control group of mice not given any opioids, and inferred that people with a history of using opioids are more susceptible to PTSD than the general population.

The study is published in Neuropsychopharmacology, an international scientific journal focusing on clinical and basic science research that advances understanding of the brain and behavior.

The research was funded by the National Institute on Drug Abuse and National Institute of Mental Health.

An opiate is a drug naturally derived from the opium poppy plant, such as heroin, morphine and codeine. Opioid is a broader term that includes opiates and any substance, natural or synthetic, that binds to the brain’s opioid receptors — which play a key role in controlling pain, rewards and addictive behaviors. Synthetic opioids include the prescription painkillers Vicodin and OxyContin, as well as fentanyl and methadone.

Substance abuse and PTSD often go hand-in-hand, Fanselow said, and people with PTSD often take drugs to self-medicate. Nearly 40% of people with PTSD also have a drug disorder.

Fanselow and colleagues reported last month that a traumatic brain injury causes changes in a brain region called the amygdala; and the brain processes fear differently after such an injury.

This article originally appeared in the UCLA Newsroom.

UCLA astronomer gets best look at first comet from outside our solar system

The comet 2I/Borisov, as seen on Oct. 12 with NASA’s Hubble Space Telescope. Scientists believe the comet is from another solar system. Photo credit: NASA, ESA and David Jewitt/UCLA

David Jewitt, a UCLA professor of planetary science and astronomy, has captured the best and sharpest look at a comet from outside of our solar system that recently barged into our own. It is the first interstellar comet astronomers have observed.

Comet 2I/Borisov (the “I” stands for interstellar) is following a path around the sun at a blazing speed of approximately 110,000 miles per hour, or about as fast as Earth travels around the sun. Jewitt studied it on Oct. 12 using NASA’s Hubble Space Telescope, which captured images of the object when it was about 260 million miles away. He observed a central concentration of dust around the comet’s solid icy nucleus — the nucleus itself is too small to be seen by Hubble — with a 100,000-mile-long dust tail streaming behind.

Jewitt said it’s very different from another interstellar object, dubbed ‘Oumuamua, that a University of Hawaii astronomer observed in 2017 before it raced out of our solar system.

“‘Oumuamua looked like a bare rock, but Borisov is really active — more like a normal comet,” said Jewitt, who leads the Hubble team. “It’s a puzzle why these two are so different. There is so much dust on this thing we’ll have to work hard to dig out the nucleus.”

That work will involve sophisticated image processing to separate the light scattered from the nucleus from light scattered by dust.

► View a 2-second time lapse video of the comet

2I/Borisov and ‘Oumuamua are the first two objects that have traveled from outside of our solar system into ours that astronomers have observed, but that’s because scientists’ knowledge and equipment are much better now than they ever have been, and because they know how to find them. One study indicates there are thousands of such comets in our solar system at any given time, although most are too faint to be detected with current telescopes.

Until 2I/Borisov, every comet that astronomers have observed originated from one of two places. One is the Kuiper belt, a region at the periphery of our solar system, beyond Neptune, that Jewitt co-discovered in 1992. The other is the Oort Cloud, a very large spherical region approximately a light-year from the sun, which astronomers think contains hundreds of billions of comets.

2I/Borisov was initially detected on Aug. 30 by Gennady Borisov at the Crimean Astrophysical Observatory, when it was 300 million miles from the sun. Jewitt said its unusually fast speed — too fast for the sun’s gravity to keep it bound in an orbit — indicates that it came from another solar system and that it is on a long path en route back to its home solar system.

Because the comet was presumably forged in a distant solar system, the comet provides valuable clues about the chemical composition and structure of the system where it originated.

2I/Borisov will be visible in the southern sky for several months. It will make its closest approach to the sun on Dec. 7, when it will be twice as far from the sun as Earth is. By the middle of 2020, it will pass Jupiter on its way back into interstellar space, where it will drift for billions of years, Jewitt said.

Comets are icy bodies thought to be fragments left behind when planets form in the outer parts of planetary systems.

20 new moons for Saturn

In separate research that has not yet been published, Jewitt is part of a team that has identified 20 previously undiscovered moons of Saturn, for a new total of 82 moons. The revised figure gives Saturn more moons than Jupiter, which has 79.

The new objects are all small, typically a few miles in diameter, and were discovered using the Subaru telescope on Maunakea in Hawaii. They can be seen only using the world’s largest telescopes, Jewitt said.

The moons might have formed in the Kuiper belt, said Jewitt, a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science and of the American Academy of Arts and Sciences.

The research team was headed by Scott Sheppard, a staff scientist at the Carnegie Institution for Science, and includes Jan Kleyna, a postdoctoral scholar at the University of Hawaii.

This article originally appeared in the UCLA Newsroom.

Minds Matter: Raising the Curtain on Depression and Anxiety

Photo of Cleveland Cavaliers basketball player Kevin Love and UCLA College’s Clinical Psychology expert Michelle Craske.

Cleveland Cavaliers basketball player Kevin Love and UCLA College’s Clinical Psychology expert Michelle Craske.

UCLA students, community members and supporters joined Cleveland Cavaliers basketball player Kevin Love and UCLA College’s Clinical Psychology expert Michelle Craske for a standing-room only hybrid class and public lecture on Monday, August 19, for “Minds Matter: Raising the Curtain on Depression and Anxiety,” a free hour-long discussion on the causes of depression and anxiety, public stigma, and potential advances for the future. The series was the first in an ongoing exploration of brain health that will continue with additional events focusing on bullying, aging well, and other topics.

Love, an NBA Champion and five-time NBA All-Star for the Cleveland Cavaliers, has publicly discussed his struggle with panic attacks and anxiety and his decision to seek therapy, and has become a leading voice in mental health advocacy and founded the Kevin Love Fund in 2018 with the mission of inspiring people to live their healthiest lives while providing the tools to achieve physical and emotional well-being.

“Mental health isn’t just an athlete thing, it’s an issue that affects everyone in some way. The more we can normalize the conversation around mental health, the more we can do to help those that are struggling,” said Love. “My goal in sharing my personal experience is to connect with others who are going through something and keep this dialogue top of mind.”

Michelle G. Craske is a UCLA Professor of Psychology, Psychiatry and Biobehavioral Sciences, Director of the Anxiety and Depression Research Center, and Associate Director of the Staglin Family Music Center for Behavioral and Brain Health. Craske has published extensively in the area of fear, anxiety and depression.

“We need to work together to bring anxiety and depression out of the dark. People who suffer will only seek help when they can do so without fear of shame. Event series such as ‘Minds Matter’ aim to shed a light on these critical issues, and to help make a positive breakthrough,” said Craske.

Craske also is Director of the Innovative Treatment Network within the UCLA Depression Grand Challenge, a campus-wide effort to cut the global burden of depression in half. The innovative treatment component, which Craske leads, seeks to develop novel and more effective treatments for depression and anxiety and increase the scalability and accessibility of existing evidence-based treatments.

The “Minds Matter” series leverages the strengths of UCLA College’s Psychology faculty as well as high-profile guests who provide specialized insight about the discussion topic. Upcoming sessions will include discussions on addiction, adolescent brain development and behavior, bullying, healthy aging, and thriving under stress. The “Minds Matter” series is made possible through the longstanding UCLA College and Geffen Playhouse partnership and the generous support of donors.

Check back for information on future “Minds Matter” events at  https://www.college.ucla.edu/minds-matter/.